Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis

Massimo Colombo, Rita Cambieri, Maria Grazia Rumi, Guido Ronchi, Ersilio Del Ninno, Roberto De Franchis

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Abstract

To assess the prevalence and clinical significance of δ-infection in chronic hepatitis B surface antigen carriers, we examined 326 liver biopsies from 192 retrospectively selected carriers by immunofluorescence. Delta antigen was detected in 102 specimens from 50 carriers (26.2%) with peak prevalence in patients with active cirrhosis (51.5%) and generally in close association with progressive liver disease (94%). The antigen was located in the nuclei of 2%-50% of the hepatocytes, without any disease-specific pattern of fluorescence. Patients with intrahepatic delta-antigen, however, had more severe liver disease than those without it. Histologic follow-up of 101 cases showed that the rates of worsening of the liver disease were similar in delta-antigen-positive and in delta-antigen-negative patients. It is concluded that delta-superinfection does play a role in worsening the histologic picture of hepatitis B surface antigen-positive chronic active hepatitis, possibly by liver injury induced acutely at the moment of infection.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalGastroenterology
Volume85
Issue number2
Publication statusPublished - 1983

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Hepatitis delta Antigens
Hepatitis D
Chronic Hepatitis
Hepatitis B Surface Antigens
Liver Diseases
Liver
Chronic Hepatitis B
Infection
Fluorescent Antibody Technique
Hepatocytes
Fibrosis
Fluorescence
Biopsy
Antigens
Wounds and Injuries

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Colombo, M., Cambieri, R., Rumi, M. G., Ronchi, G., Del Ninno, E., & De Franchis, R. (1983). Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis. Gastroenterology, 85(2), 235-239.

Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis. / Colombo, Massimo; Cambieri, Rita; Rumi, Maria Grazia; Ronchi, Guido; Del Ninno, Ersilio; De Franchis, Roberto.

In: Gastroenterology, Vol. 85, No. 2, 1983, p. 235-239.

Research output: Contribution to journalArticle

Colombo, M, Cambieri, R, Rumi, MG, Ronchi, G, Del Ninno, E & De Franchis, R 1983, 'Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis', Gastroenterology, vol. 85, no. 2, pp. 235-239.
Colombo, Massimo ; Cambieri, Rita ; Rumi, Maria Grazia ; Ronchi, Guido ; Del Ninno, Ersilio ; De Franchis, Roberto. / Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis. In: Gastroenterology. 1983 ; Vol. 85, No. 2. pp. 235-239.
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