TY - JOUR
T1 - Long-term effect of arsenic exposure
T2 - Results from an occupational cohort study
AU - Gianicolo, Emilio Antonio L.
AU - Mangia, Cristina
AU - Cervino, Marco
AU - Bruni, Antonella
AU - Portaluri, Maurizio
AU - Comba, Pietro
AU - Pirastu, Roberta
AU - Biggeri, Annibale
AU - Vigotti, Mariangela
AU - Blettner, Maria
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Background: In 1976 in Manfredonia (Italy), arsenic was released into the atmosphere due to an accident in a petrochemical plant. We aimed to analyze the mortality of workers involved in the factory for the site cleaning activities. Methods: The cohort consisted of 1467 workers grouped into contract, fertilizer, and plastic workers. The outcome of interest was mortality for specific causes. Standardized mortality ratios (SMR) and 95% confidence intervals (95%CI) were computed. Results: For all workers and all causes of death combined, the SMR was less than 1.0. Mortality ratios were increased for malignant neoplasms of the pleura, bone and melanoma of the skin. Contract workers, the group mostly exposed to arsenic, showed statistically significant SMRs for several malignancies, in particular for lung cancer (SMR = 1.26; 95%CI: 1.05-1.54). Conclusions: Overall, the results reported here on mortality among persons occupationally exposed to arsenic are consistent with the literature and biologically plausible.
AB - Background: In 1976 in Manfredonia (Italy), arsenic was released into the atmosphere due to an accident in a petrochemical plant. We aimed to analyze the mortality of workers involved in the factory for the site cleaning activities. Methods: The cohort consisted of 1467 workers grouped into contract, fertilizer, and plastic workers. The outcome of interest was mortality for specific causes. Standardized mortality ratios (SMR) and 95% confidence intervals (95%CI) were computed. Results: For all workers and all causes of death combined, the SMR was less than 1.0. Mortality ratios were increased for malignant neoplasms of the pleura, bone and melanoma of the skin. Contract workers, the group mostly exposed to arsenic, showed statistically significant SMRs for several malignancies, in particular for lung cancer (SMR = 1.26; 95%CI: 1.05-1.54). Conclusions: Overall, the results reported here on mortality among persons occupationally exposed to arsenic are consistent with the literature and biologically plausible.
KW - arsenic
KW - epidemiology of disasters
KW - industrial accident
KW - lung cancer
KW - petrochemical plant
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U2 - 10.1002/ajim.22939
DO - 10.1002/ajim.22939
M3 - Article
C2 - 30609098
AN - SCOPUS:85059560446
VL - 62
SP - 145
EP - 155
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
SN - 0271-3586
IS - 2
ER -