Long-term effectiveness and safety of a nutraceutical based approach to reduce cholesterolemia in statin intolerant subjects with and without metabolic syndrome

Arrigo F G Cicero, G. Derosa, M. Bove, F. Imola, C. Borghi, A. V. Gaddi

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of our study was to test the long-term effectiveness and tolerability of a nutraceutical based approach in reducing cholesterolemia in statin intolerant subjects with and without metabolic syndrome in primary prevention for cardiovascular disease. We carried out a prospective, clinical trial enrolling 48 subjects intolerant to more than one statin. Patients assumed one yogurt added with 2 g phytostanols each morning (Pro-Activ® , Unilever Italy, Milan, Italy) and one pills of a registered combined nutraceutical (Armolipid Plus® , Rottapharm-Madaus Srl, Monza, Italy) containing Berberine 500 mg and Monacoline 3 mg. Four patients dropped out from the study because of side effects (2 asymptomatic increase in CPK>5 ULN, 1 myalgia, 1 dyspepsia). After 3 months, total cholesterol decreased by 22.3±5.8%, LDL-C by 31.3±8.3%, TG by 16.11±10.7% (all, p

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalCurrent Topics in Nutraceutical Research
Volume7
Issue number3-4
Publication statusPublished - Aug 2009

Keywords

  • Berberine
  • Hypercholesterolemia
  • Nutraceuticals
  • Phytosterols
  • Statin intolerance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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