TY - JOUR
T1 - Long-term effectiveness of resection and radiofrequency ablation for single hepatocellular carcinoma ≤3 cm. Results of a multicenter Italian survey
AU - Pompili, Maurizio
AU - Saviano, Antonio
AU - De Matthaeis, Nicoletta
AU - Cucchetti, Alessandro
AU - Ardito, Francesco
AU - Federico, Bruno
AU - Brunello, Franco
AU - Pinna, Antonio D.
AU - Giorgio, Antonio
AU - Giulini, Stefano M.
AU - De Sio, Ilario
AU - Torzilli, Guido
AU - Fornari, Fabio
AU - Capussotti, Lorenzo
AU - Guglielmi, Alfredo
AU - Piscaglia, Fabio
AU - Aldrighetti, Luca
AU - Caturelli, Eugenio
AU - Calise, Fulvio
AU - Nuzzo, Gennaro
AU - Rapaccini, Gian Ludovico
AU - Giuliante, Felice
PY - 2013/7
Y1 - 2013/7
N2 - Background & Aims The aim of this study was to compare liver resection and radiofrequency ablation in patients with single hepatocellular carcinoma ≤3 cm and compensated cirrhosis. Methods The study involved 544 Child-Pugh A cirrhotic patients (246 in the resection group and 298 in the radiofrequency group) observed in 15 Italian centers. Overall survival and tumor recurrence rates were analyzed using the Kaplan Meier method before and after propensity score matching. Cox regression models were used to identify factors associated with overall survival and tumor recurrence. Results Two cases of perioperative mortality were observed in the resection group and the rate of major complications was 4.5% in the resection group and 2.0% in the radiofrequency group (p = 0.101). Four-year overall survival rates were 74.4% in the resection group and 66.2% in the radiofrequency group (p = 0.353). Four-year cumulative HCC recurrence rates were 56% in the resection group and 57.1% in the radiofrequency group (p = 0.765). Local tumor progression was detected in 20.5% of ablated patients and in one resected patient (p
AB - Background & Aims The aim of this study was to compare liver resection and radiofrequency ablation in patients with single hepatocellular carcinoma ≤3 cm and compensated cirrhosis. Methods The study involved 544 Child-Pugh A cirrhotic patients (246 in the resection group and 298 in the radiofrequency group) observed in 15 Italian centers. Overall survival and tumor recurrence rates were analyzed using the Kaplan Meier method before and after propensity score matching. Cox regression models were used to identify factors associated with overall survival and tumor recurrence. Results Two cases of perioperative mortality were observed in the resection group and the rate of major complications was 4.5% in the resection group and 2.0% in the radiofrequency group (p = 0.101). Four-year overall survival rates were 74.4% in the resection group and 66.2% in the radiofrequency group (p = 0.353). Four-year cumulative HCC recurrence rates were 56% in the resection group and 57.1% in the radiofrequency group (p = 0.765). Local tumor progression was detected in 20.5% of ablated patients and in one resected patient (p
KW - Hepatocellular carcinoma
KW - Liver resection
KW - Long-term effectiveness
KW - Overall survival
KW - Propensity score matching
KW - Radiofrequency ablation
KW - Tumor recurrence
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U2 - 10.1016/j.jhep.2013.03.009
DO - 10.1016/j.jhep.2013.03.009
M3 - Article
C2 - 23523578
AN - SCOPUS:84879172802
VL - 59
SP - 89
EP - 97
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 1
ER -