Long-term effectiveness of resection and radiofrequency ablation for single hepatocellular carcinoma ≤3 cm. Results of a multicenter Italian survey

Maurizio Pompili, Antonio Saviano, Nicoletta De Matthaeis, Alessandro Cucchetti, Francesco Ardito, Bruno Federico, Franco Brunello, Antonio D. Pinna, Antonio Giorgio, Stefano M. Giulini, Ilario De Sio, Guido Torzilli, Fabio Fornari, Lorenzo Capussotti, Alfredo Guglielmi, Fabio Piscaglia, Luca Aldrighetti, Eugenio Caturelli, Fulvio Calise, Gennaro Nuzzo & 2 others Gian Ludovico Rapaccini, Felice Giuliante

Research output: Contribution to journalArticle

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Abstract

Background & Aims The aim of this study was to compare liver resection and radiofrequency ablation in patients with single hepatocellular carcinoma ≤3 cm and compensated cirrhosis. Methods The study involved 544 Child-Pugh A cirrhotic patients (246 in the resection group and 298 in the radiofrequency group) observed in 15 Italian centers. Overall survival and tumor recurrence rates were analyzed using the Kaplan Meier method before and after propensity score matching. Cox regression models were used to identify factors associated with overall survival and tumor recurrence. Results Two cases of perioperative mortality were observed in the resection group and the rate of major complications was 4.5% in the resection group and 2.0% in the radiofrequency group (p = 0.101). Four-year overall survival rates were 74.4% in the resection group and 66.2% in the radiofrequency group (p = 0.353). Four-year cumulative HCC recurrence rates were 56% in the resection group and 57.1% in the radiofrequency group (p = 0.765). Local tumor progression was detected in 20.5% of ablated patients and in one resected patient (p

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalJournal of Hepatology
Volume59
Issue number1
DOIs
Publication statusPublished - Jul 2013

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Hepatocellular Carcinoma
Recurrence
Neoplasms
Propensity Score
Survival
Proportional Hazards Models
Fibrosis
Survival Rate
Mortality
Surveys and Questionnaires
Liver

Keywords

  • Hepatocellular carcinoma
  • Liver resection
  • Long-term effectiveness
  • Overall survival
  • Propensity score matching
  • Radiofrequency ablation
  • Tumor recurrence

ASJC Scopus subject areas

  • Hepatology

Cite this

Long-term effectiveness of resection and radiofrequency ablation for single hepatocellular carcinoma ≤3 cm. Results of a multicenter Italian survey. / Pompili, Maurizio; Saviano, Antonio; De Matthaeis, Nicoletta; Cucchetti, Alessandro; Ardito, Francesco; Federico, Bruno; Brunello, Franco; Pinna, Antonio D.; Giorgio, Antonio; Giulini, Stefano M.; De Sio, Ilario; Torzilli, Guido; Fornari, Fabio; Capussotti, Lorenzo; Guglielmi, Alfredo; Piscaglia, Fabio; Aldrighetti, Luca; Caturelli, Eugenio; Calise, Fulvio; Nuzzo, Gennaro; Rapaccini, Gian Ludovico; Giuliante, Felice.

In: Journal of Hepatology, Vol. 59, No. 1, 07.2013, p. 89-97.

Research output: Contribution to journalArticle

Pompili, M, Saviano, A, De Matthaeis, N, Cucchetti, A, Ardito, F, Federico, B, Brunello, F, Pinna, AD, Giorgio, A, Giulini, SM, De Sio, I, Torzilli, G, Fornari, F, Capussotti, L, Guglielmi, A, Piscaglia, F, Aldrighetti, L, Caturelli, E, Calise, F, Nuzzo, G, Rapaccini, GL & Giuliante, F 2013, 'Long-term effectiveness of resection and radiofrequency ablation for single hepatocellular carcinoma ≤3 cm. Results of a multicenter Italian survey', Journal of Hepatology, vol. 59, no. 1, pp. 89-97. https://doi.org/10.1016/j.jhep.2013.03.009
Pompili, Maurizio ; Saviano, Antonio ; De Matthaeis, Nicoletta ; Cucchetti, Alessandro ; Ardito, Francesco ; Federico, Bruno ; Brunello, Franco ; Pinna, Antonio D. ; Giorgio, Antonio ; Giulini, Stefano M. ; De Sio, Ilario ; Torzilli, Guido ; Fornari, Fabio ; Capussotti, Lorenzo ; Guglielmi, Alfredo ; Piscaglia, Fabio ; Aldrighetti, Luca ; Caturelli, Eugenio ; Calise, Fulvio ; Nuzzo, Gennaro ; Rapaccini, Gian Ludovico ; Giuliante, Felice. / Long-term effectiveness of resection and radiofrequency ablation for single hepatocellular carcinoma ≤3 cm. Results of a multicenter Italian survey. In: Journal of Hepatology. 2013 ; Vol. 59, No. 1. pp. 89-97.
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abstract = "Background & Aims The aim of this study was to compare liver resection and radiofrequency ablation in patients with single hepatocellular carcinoma ≤3 cm and compensated cirrhosis. Methods The study involved 544 Child-Pugh A cirrhotic patients (246 in the resection group and 298 in the radiofrequency group) observed in 15 Italian centers. Overall survival and tumor recurrence rates were analyzed using the Kaplan Meier method before and after propensity score matching. Cox regression models were used to identify factors associated with overall survival and tumor recurrence. Results Two cases of perioperative mortality were observed in the resection group and the rate of major complications was 4.5{\%} in the resection group and 2.0{\%} in the radiofrequency group (p = 0.101). Four-year overall survival rates were 74.4{\%} in the resection group and 66.2{\%} in the radiofrequency group (p = 0.353). Four-year cumulative HCC recurrence rates were 56{\%} in the resection group and 57.1{\%} in the radiofrequency group (p = 0.765). Local tumor progression was detected in 20.5{\%} of ablated patients and in one resected patient (p",
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AU - Pompili, Maurizio

AU - Saviano, Antonio

AU - De Matthaeis, Nicoletta

AU - Cucchetti, Alessandro

AU - Ardito, Francesco

AU - Federico, Bruno

AU - Brunello, Franco

AU - Pinna, Antonio D.

AU - Giorgio, Antonio

AU - Giulini, Stefano M.

AU - De Sio, Ilario

AU - Torzilli, Guido

AU - Fornari, Fabio

AU - Capussotti, Lorenzo

AU - Guglielmi, Alfredo

AU - Piscaglia, Fabio

AU - Aldrighetti, Luca

AU - Caturelli, Eugenio

AU - Calise, Fulvio

AU - Nuzzo, Gennaro

AU - Rapaccini, Gian Ludovico

AU - Giuliante, Felice

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N2 - Background & Aims The aim of this study was to compare liver resection and radiofrequency ablation in patients with single hepatocellular carcinoma ≤3 cm and compensated cirrhosis. Methods The study involved 544 Child-Pugh A cirrhotic patients (246 in the resection group and 298 in the radiofrequency group) observed in 15 Italian centers. Overall survival and tumor recurrence rates were analyzed using the Kaplan Meier method before and after propensity score matching. Cox regression models were used to identify factors associated with overall survival and tumor recurrence. Results Two cases of perioperative mortality were observed in the resection group and the rate of major complications was 4.5% in the resection group and 2.0% in the radiofrequency group (p = 0.101). Four-year overall survival rates were 74.4% in the resection group and 66.2% in the radiofrequency group (p = 0.353). Four-year cumulative HCC recurrence rates were 56% in the resection group and 57.1% in the radiofrequency group (p = 0.765). Local tumor progression was detected in 20.5% of ablated patients and in one resected patient (p

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