Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: A case series

Simona Bertoli, Claudia Trentani, Cinzia Ferraris, Valentina De Giorgis, Pierangelo Veggiotti, Anna Tagliabue

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The only known treatment of glucose transporter 1 deficiency syndrome (GLUT-1 DS) is a ketogenic diet (KD), which provides the brain with an alternative fuel. Studies in children with intractable epilepsy have shown that a prolonged KD can induce a progressive loss of bonemineral content associated with poor bone health status, probably as a consequence ofachronic acidic environment. The aim of this study is to determine the long-term effects of aKD on body composition and bone mineral status of patients with GLUT-1 DS, is currently unknown. Methods: In this case series, we report the changes in body composition and bone mineral status observed in three adult patients with GLUT-1 DS who have been treated with a KD for more than 5 y. Results: A long-term KD did not produce appreciable changes in weight and body composition of adults with GLUT-1 DS. Moreover, we found no evidence of potential adverse effects of a KD on bone health. In summary, this case series contributes to a small but growing body of literature that investigated the potential long-term effects of a KD on bone health. Conclusions: Our data suggest that maintaining a KD for more than 5 y does not pose any major negative effects on body composition, bone mineral content, and bone mineral density in adults with GLUT-1 DS, a finding that is at variance with previous reports focusing on children with intractable epilepsy. Further studies with larger sizes are needed to confirm and expand our findings.

Original languageEnglish
Pages (from-to)726-728
Number of pages3
JournalNutrition
Volume30
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Body composition
  • Bone health
  • Glucose transporter 1 deficiency syndrome
  • Ketogenic diet

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Medicine(all)

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