Long-term effects of amlodipine versus fosinopril on microalbuminuria in elderly hypertensive patients with type 2 diabetes mellitus

Roberto Fogari, Annalisa Zoppi, Luca Corradi, Luigi Poletti, Michele Pasotti, Elena Fogari, Amedeo Mugellini

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: The aim of this study was to compare the effects on urinary albumin excretion (UAE) of amlodipine versus fosinopril in elderly hypertensive patients with type 2 diabetes mellitus. Methods: We studied 147 elderly (60 to 75 years) hypertensive patients (diastolic blood pressure > 90 mm Hg) with concomitant, well-controlled type 2 diabetes mellitus. After a 4- week placebo period (at the beginning of which current antihypertensive agents were discontinued), they were randomly allocated to receive amlodipine 5 to 10 mg once daily (n = 73) or fosinopril 10 to 20 mg once dally (n = 74) for 24 months. Nonresponders to monotherapy were discontinued after 8 weeks. At the end of the placebo period and after 3, 6, 12, 18, and 24 months of treatment, blood pressure (BP), glycosylated hemoglobin A(1c), UAE, and creatinine clearance were determined. Results: Seventy-nine patients completed the 24-month study. Both amlodipine and fosinoprll similarly reduced BP without affecting glucose homeostasis. At 3 months, UAE was significantly reduced (P <0.01) only in the fosinopril-treated patients; however, at 12 and 24 months, it was significantly decreased with both drugs (fosinopril, P <0.01; amlodipine, P <0.05). Creatinine clearance was unaffected by fosinopril but was significantly increased (P <0.05) by amlodipine at 12 months. Conclusions: Based on these results, we concluded that long-term treatment with both amlodipine and fosinopril was effective in reducing UAE in elderly hypertensive patients with type 2 diabetes mellitus and microalbuminuria.

Original languageEnglish
Pages (from-to)163-173
Number of pages11
JournalCurrent Therapeutic Research
Volume61
Issue number3
DOIs
Publication statusPublished - 2000

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Fosinopril
Amlodipine
Type 2 Diabetes Mellitus
Albumins
Blood Pressure
Creatinine
Placebos
Glycosylated Hemoglobin A
Antihypertensive Agents
Homeostasis
Glucose
Therapeutics
Pharmaceutical Preparations

Keywords

  • Amlodipine
  • Elderly
  • Fosinopril
  • Type 2 diabetes mellitus
  • Urinary albumin excretion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Long-term effects of amlodipine versus fosinopril on microalbuminuria in elderly hypertensive patients with type 2 diabetes mellitus. / Fogari, Roberto; Zoppi, Annalisa; Corradi, Luca; Poletti, Luigi; Pasotti, Michele; Fogari, Elena; Mugellini, Amedeo.

In: Current Therapeutic Research, Vol. 61, No. 3, 2000, p. 163-173.

Research output: Contribution to journalArticle

Fogari, Roberto ; Zoppi, Annalisa ; Corradi, Luca ; Poletti, Luigi ; Pasotti, Michele ; Fogari, Elena ; Mugellini, Amedeo. / Long-term effects of amlodipine versus fosinopril on microalbuminuria in elderly hypertensive patients with type 2 diabetes mellitus. In: Current Therapeutic Research. 2000 ; Vol. 61, No. 3. pp. 163-173.
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AU - Zoppi, Annalisa

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AU - Poletti, Luigi

AU - Pasotti, Michele

AU - Fogari, Elena

AU - Mugellini, Amedeo

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AB - Objective: The aim of this study was to compare the effects on urinary albumin excretion (UAE) of amlodipine versus fosinopril in elderly hypertensive patients with type 2 diabetes mellitus. Methods: We studied 147 elderly (60 to 75 years) hypertensive patients (diastolic blood pressure > 90 mm Hg) with concomitant, well-controlled type 2 diabetes mellitus. After a 4- week placebo period (at the beginning of which current antihypertensive agents were discontinued), they were randomly allocated to receive amlodipine 5 to 10 mg once daily (n = 73) or fosinopril 10 to 20 mg once dally (n = 74) for 24 months. Nonresponders to monotherapy were discontinued after 8 weeks. At the end of the placebo period and after 3, 6, 12, 18, and 24 months of treatment, blood pressure (BP), glycosylated hemoglobin A(1c), UAE, and creatinine clearance were determined. Results: Seventy-nine patients completed the 24-month study. Both amlodipine and fosinoprll similarly reduced BP without affecting glucose homeostasis. At 3 months, UAE was significantly reduced (P <0.01) only in the fosinopril-treated patients; however, at 12 and 24 months, it was significantly decreased with both drugs (fosinopril, P <0.01; amlodipine, P <0.05). Creatinine clearance was unaffected by fosinopril but was significantly increased (P <0.05) by amlodipine at 12 months. Conclusions: Based on these results, we concluded that long-term treatment with both amlodipine and fosinopril was effective in reducing UAE in elderly hypertensive patients with type 2 diabetes mellitus and microalbuminuria.

KW - Amlodipine

KW - Elderly

KW - Fosinopril

KW - Type 2 diabetes mellitus

KW - Urinary albumin excretion

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