TY - JOUR
T1 - Long-term effects of early environment on the brain
T2 - Lesson from rodent models
AU - Di Segni, Matteo
AU - Andolina, Diego
AU - Ventura, Rossella
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The postnatal period is characterized by extensive neuronal plasticity, synaptic organization, and remodeling. High neuroplasticity renders the brain sensitive to the remodeling effects induced by environmental factors, such as exposure to adversity, which can imprint neurochemical, neuroendocrine, morphological, and behavioral changes.Early experiences that influence developmental trajectories during maturation of the brain can have a wide range of long-lasting effects, modulating stress-coping strategies in adult life and inducing vulnerability or resilience to psychopathologies, depending on the gene. ×. later experience interplay.Future studies will clarify how manipulation of the early environment induces these effects acting on genetic and epigenetic factors.
AB - The postnatal period is characterized by extensive neuronal plasticity, synaptic organization, and remodeling. High neuroplasticity renders the brain sensitive to the remodeling effects induced by environmental factors, such as exposure to adversity, which can imprint neurochemical, neuroendocrine, morphological, and behavioral changes.Early experiences that influence developmental trajectories during maturation of the brain can have a wide range of long-lasting effects, modulating stress-coping strategies in adult life and inducing vulnerability or resilience to psychopathologies, depending on the gene. ×. later experience interplay.Future studies will clarify how manipulation of the early environment induces these effects acting on genetic and epigenetic factors.
KW - Animal models
KW - Early environment
KW - Gene-environment interplay
KW - Plasticity
KW - Postnatal manipulations
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U2 - 10.1016/j.semcdb.2017.09.039
DO - 10.1016/j.semcdb.2017.09.039
M3 - Article
AN - SCOPUS:85030626672
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
ER -