Long-term effects of fenretinide on retinal function

A. Decensi, V. Fontana, M. Fioretto, G. Rondanina, R. Torrisi, M. A. Orengo, A. Costa

Research output: Contribution to journalArticle

Abstract

The long-term effects of the synthetic retinoid fenretinide (4-HPR) on retinal function were studied by electroretinogram (ERG) in 24 women treated for a median of 30.5 months and in 18 untreated controls belonging to a phase III intervention trial. The six outcome measures were: a wave implicit time, peak-to-peak amplitude and implicit time of b wave following both cone stimulation and maximal cone-rod stimulation in the dark-adapted eye. Multivariate analysis of covariance was applied to evaluate the joint effect on the whole set of ERG measures taking into account their inter-relationship. Predictive factors with a significant effect on ERG measures were: (1) a qualitative interaction between age and treatment duration and (2) the squared (parabolic) function of plasma retinol. Individually, the b wave implicit time following cone stimulation was the only ERG measure significantly influenced by the predictors, indicating a primary effect of 4-HPR on retinal photoreceptor sensitivity without significant alterations of the inner nuclear layer. Thus, in contrast to previous reports at higher dose, administration of 4-HPR at 200 mg/day seems to exert subtle alterations of retinal function as measured by ERG.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalEuropean Journal of Cancer
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 1997

Fingerprint

Fenretinide
Vertebrate Photoreceptor Cells
Retinoids
Vitamin A
Multivariate Analysis
Outcome Assessment (Health Care)

Keywords

  • cancer prevention
  • retinal effects
  • retinoids

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Long-term effects of fenretinide on retinal function. / Decensi, A.; Fontana, V.; Fioretto, M.; Rondanina, G.; Torrisi, R.; Orengo, M. A.; Costa, A.

In: European Journal of Cancer, Vol. 33, No. 1, 01.1997, p. 80-84.

Research output: Contribution to journalArticle

Decensi, A, Fontana, V, Fioretto, M, Rondanina, G, Torrisi, R, Orengo, MA & Costa, A 1997, 'Long-term effects of fenretinide on retinal function', European Journal of Cancer, vol. 33, no. 1, pp. 80-84. https://doi.org/10.1016/S0959-8049(96)00351-6
Decensi, A. ; Fontana, V. ; Fioretto, M. ; Rondanina, G. ; Torrisi, R. ; Orengo, M. A. ; Costa, A. / Long-term effects of fenretinide on retinal function. In: European Journal of Cancer. 1997 ; Vol. 33, No. 1. pp. 80-84.
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