Long-term effects of oral contraceptives on ovarian cancer risk

Cristina Bosetti, Eva Negri, Dimitrios Trichopoulos, Silvia Franceschi, Valerie Beral, Anastasia Tzonou, Fabio Parazzini, Stefano Greggi, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


Several epidemiologic studies have reported a protective effect of oral contraceptives (OCs) on ovarian cancer. However, there remain open issues, including better quantification of time-related factors such as time since last use, age at first use and time since first use. We performed a collaborative reanalysis of 6 case-control studies conducted between 1978 and 1999 in the United Kingdom, Greece and Italy, including a total of 2,768 incident, histologically confirmed cases of epithelial ovarian cancer and 6,274 hospital controls under age 70 years. A reduced risk of ovarian cancer was found for ever- compared to never-users [odds ratio (OR) = 0.66, 95% confidence interval (CI) 0.56-0.79], and a stronger reduction was observed for women who had used OCs for ≥5 years (OR = 0.50, 95% CI 0.33-0.76) compared to those who had used them for

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalInternational Journal of Cancer
Issue number3
Publication statusPublished - Nov 20 2002


  • Case-control study
  • Oral contraceptive
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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