Long-term effects of parenteral dichloromethylene bisphosphonate (CL2MBP) on bone disease of myeloma patients treated with chemotherapy

G. Merlini, G. A. Parrinello, L. Piccinini, F. Crema, M. L. Fiorentini, A. Riccardi, F. Pavesi, F. Novazzi, V. Silingardi, E. Ascari

Research output: Contribution to journalArticle

Abstract

Data on the long-term treatment of myeloma bone disease with bisphosphonates are scanty. In a prospective pilot trial we evaluated the effect of long-term parenteral administration of dichloromethylene bisphosphonate (Clodronate), in addition to standard chemotherapy, in 30 patients with active myeloma bone disease. Patients were treated with a mean of 4 courses (range 2-8) of Clodronate: 300 mg/day i.v. for seven days followed by 100 mg/day i.m. for 10 days, administered at a mean interval of 4 months (range 3-6). The median follow-up was 24 months (range 8-36). Clodronate reduced bone pain rapidly and significantly, and reduced the mean values of the biochemical indices of bone resorption to within normal limits; these effects were maintained throughout the follow-up. In three hypercalcemic episodes serum calcium became normal after 2-5 days of treatment with Clodronate. No toxic or side effects were noticed. The occurrence of skeletal morbidity in patients treated with Clodronate was compared with that observed in the control group of myeloma patients treated with chemotherapy only: Clodronate provided a significant reduction (p

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalHematological Oncology
Volume8
Issue number1
Publication statusPublished - 1990

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Merlini, G., Parrinello, G. A., Piccinini, L., Crema, F., Fiorentini, M. L., Riccardi, A., Pavesi, F., Novazzi, F., Silingardi, V., & Ascari, E. (1990). Long-term effects of parenteral dichloromethylene bisphosphonate (CL2MBP) on bone disease of myeloma patients treated with chemotherapy. Hematological Oncology, 8(1), 23-30.