Long-term effects of radiotherapy on cardiovascular risk factors in acromegaly

Cristina L. Ronchi, Elisa Verrua, Emanuele Ferrante, Gwendolyn Bender, Elisa Sala, Andrea G. Lania, Martin Fassnacht, Paolo Beck-Peccoz, Bruno Allolio, Anna Spada, Maura Arosio

Research output: Contribution to journalArticle

Abstract

Objective: Radiation therapy (RT) is a useful adjuvant tool for acromegalic patients not cured by surgery and/or not responding to pharmacotherapy. However, its specific effects on cardio- and cerebrovascular morbidity are still on debate. Design: Retrospective analysis of 42 acromegalic patients cured after conventional radiotherapy (CRT, n=31) or radiosurgery by gamma-knife (GKRS, n=11) followed for a median period of 16.5 years (range: 2-40). Totally, 56 patients cured by surgery alone, with similar GH/IGF1 levels and duration of disease remission, served as control group. Methods: Changes in cardiovascular risk factors, such as body mass index, glucose metabolism, insulin resistance, blood pressure, and lipid profile (pre-defined primary end point) and occurrence of new major cardio- and cerebrovascular events (secondary end point) during follow-up. Results: The number of obese, hypertensive, and dyslipidemic subjects increased over time only in patients cured with RT. In contrast, the glucose response to the oral glucose tolerance test and the percentage of subjects with glucose alterations improved only in controls. As expected, the percentage of patients with pituitary failure was deeply higher among RT patients than among controls (86 vs 30%, P

Original languageEnglish
Pages (from-to)675-684
Number of pages10
JournalEuropean Journal of Endocrinology
Volume164
Issue number5
DOIs
Publication statusPublished - May 1 2011

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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    Ronchi, C. L., Verrua, E., Ferrante, E., Bender, G., Sala, E., Lania, A. G., Fassnacht, M., Beck-Peccoz, P., Allolio, B., Spada, A., & Arosio, M. (2011). Long-term effects of radiotherapy on cardiovascular risk factors in acromegaly. European Journal of Endocrinology, 164(5), 675-684. https://doi.org/10.1530/EJE-10-1105