Long-term effects of vaccination on attentional performance

Roberto Nicoletti, Carlo Adolfo Porro, Gianni Brighetti, Daniela Monti, Giuseppe Pagnoni, Marcello Guido, Sandro Rubichi, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review


To investigate the possible influence of stimulation of the immune system on cognitive tasks, healthy volunteers were vaccinated against hepatitis B and tested over a 6 month-period in a simple reaction times and the Stroop task. In general, the "Stroop effect" demonstrates that both the name and meaning of a word are automatically processed even when voluntary attention is trying hard not to process them. Unlike placebo group, vaccinated subjects showed a persistent lack of the classical Stroop effect. These findings may be explained by a constraint satisfaction model of the Stroop task, assuming a selective weakening of the connection matrix, and suggest that immune-cognitive effects may occur, besides the well known immune-cognitive influences like those elicited by emotional stress.

Original languageEnglish
Pages (from-to)3877-3881
Number of pages5
Issue number29-30
Publication statusPublished - Sep 28 2004


  • Attention
  • Immune-cognitive effects
  • Stroop task

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)


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