Long-term effects on corneal keratocytes of mitomycin C during photorefractive keratectomy: A randomized contralateral eye confocal microscopy study

Edoardo Midena, Catia Gambato, Stefania Miotto, Marta Cortese, Rudy Salvi, Alessandra Ghirlando

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To evaluate the long-term side effects of mitomycin C (MMC) assisted photorefractive keratectomy (PRK) on corneal keratocytes of highly myopic eyes. METHODS: Twenty-eight patients with bilateral myopia from -7.00 to -14.25 diopters (D) underwent PRK on both eyes, one eye of each patient received topical application of 0.02% MMC for 2 minutes immediately after the PRK procedure. Corneal keratocyte density was quantified by corneal confocal microscopy at baseline and 5 years postoperatively. RESULTS: Photorefractive keratectomy reduced keratocyte density in the most anterior stromal layer, without a statistically significant difference between MMC and standard treated eyes. Posterior stromal layers showed no signs of keratocyte loss with either techniques. CONCLUSIONS: Phototherapeutic keratectomy with 0.02% topical MMC has no significant side effects on corneal keratocytes compared to standard PRK, as documented by in vivo corneal confocal microscopy.

Original languageEnglish
JournalJournal of Refractive Surgery
Volume23
Issue number9 SUPPL.
Publication statusPublished - Nov 2007

ASJC Scopus subject areas

  • Ophthalmology

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