Long-term effects on left ventricular function after late thrombolysis in patients with myocardial infarction

Antonio Liguori, Fernando Di Gregorio, Maurizio Leccese, Angelo Montemarano, Nicola Di Ieso, Luigi Mansi, Ciaudio Napoli

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This open-label, uncontrolled, retrospective study assessed the long-term effects of late thrombolysis on left ventricular (LV) function. We studied 79 patients (52 men and 27 women; mean age, 51 ± 5 years) treated with alteplase (group 1) and 46 patients (33 men and 13 women; mean age, 52 ± 8 years) treated with heparin alone (group 2) at their first myocardial infarction (MI). Patients were eligible for the study if they were younger than 62 years, their duration of pain was longer than 6 hours, and they had no episodes of angina in the 48 hours preceding their MI. The peak of creatine kinase-muscle and brain subunits was significantly less in group 1 than group 2 (106 ± 67 vs 205 ± 102 IU/L). Both LV ejection fraction and wall-motion score were better in thrombolysed patients, and the cumulative frequency of radionuclide defects was higher in these patients during the 4-year follow-up. Our study supports the concept that thrombolysis reduces the incidence of long-term post-MI residual ischemia, improving global LV function even when given late after the onset of MI symptoms.

Original languageEnglish
Pages (from-to)570-574
Number of pages5
JournalCurrent Therapeutic Research
Issue number9
Publication statusPublished - 1997


  • Left ventricular function
  • Myocardial infarction
  • Myocardial ischemia
  • Regional function
  • Thrombolysis

ASJC Scopus subject areas

  • Medicine(all)


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