Efficacia e tollerabilita del Topiramato nella terapia aggiuntiva a lungo termine: Analisi ad interim dopo quattro anni di trattamento

In this open trial efficacy and tolerability of topiramate add-on long term administration have been evaluted in patients with uncontrolled epilepsy of any seizure type 67 patients from 4 Italian centres were studied. TPM was added-on four standard AED's. After TPM titration, a maintenance period with the optimal efficacy dose has been reached in 64 patients. After 3 years, the mean duration of treatment was 9,5 months (± 7,6 d.s), the mean dose of TPM was 274 (± 144) mg/day. The reduction of seizure frequency was obteined in 30% of patients; 75% reduction occurred in 14% and 8% was seizure-free. 19,4% of patients dropped-out for adverse events, 22,4% for inefficacy.