Efficacia e tollerabilita del Topiramato nella terapia aggiuntiva a lungo termine: Analisi ad interim dopo quattro anni di trattamento

R. Canger; G. Avanzini; A. Tartara; C. Durisotti; L. Guidolin; S. Binelli; L. Canafoglia; L. Sartori; P. Garofalo; F. Pozzi; V. Silenzi; D. Bertelletti; M. Di Fazio; E. Perucca

Efficacia e tollerabilita del Topiramato nella terapia aggiuntiva a lungo termine: Analisi ad interim dopo quattro anni di trattamento

Translated title of the contribution: Long term efficacy and tolerability of Topiramate add-on terapy: Interim analysis after four years treatment

R. Canger, G. Avanzini, A. Tartara, C. Durisotti, L. Guidolin, S. Binelli, L. Canafoglia, L. Sartori, P. Garofalo, F. Pozzi, V. Silenzi, D. Bertelletti, M. Di Fazio, E. Perucca

Research output: Contribution to journal › Article › peer-review

Abstract

In this open trial efficacy and tolerability of topiramate add-on long term administration have been evaluted in patients with uncontrolled epilepsy of any seizure type 67 patients from 4 Italian centres were studied. TPM was added-on four standard AED's. After TPM titration, a maintenance period with the optimal efficacy dose has been reached in 64 patients. After 3 years, the mean duration of treatment was 9,5 months (± 7,6 d.s), the mean dose of TPM was 274 (± 144) mg/day. The reduction of seizure frequency was obteined in 30% of patients; 75% reduction occurred in 14% and 8% was seizure-free. 19,4% of patients dropped-out for adverse events, 22,4% for inefficacy.

Translated title of the contribution	Long term efficacy and tolerability of Topiramate add-on terapy: Interim analysis after four years treatment
Original language	Italian
Pages (from-to)	105-107
Number of pages	3
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	99
Publication status	Published - 1997

ASJC Scopus subject areas

Clinical Neurology

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Canger, R., Avanzini, G., Tartara, A., Durisotti, C., Guidolin, L., Binelli, S., Canafoglia, L., Sartori, L., Garofalo, P., Pozzi, F., Silenzi, V., Bertelletti, D., Di Fazio, M., & Perucca, E. (1997). Efficacia e tollerabilita del Topiramato nella terapia aggiuntiva a lungo termine: Analisi ad interim dopo quattro anni di trattamento. Bollettino - Lega Italiana contro l'Epilessia, (99), 105-107.

Efficacia e tollerabilita del Topiramato nella terapia aggiuntiva a lungo termine : Analisi ad interim dopo quattro anni di trattamento. / Canger, R.; Avanzini, G.; Tartara, A.; Durisotti, C.; Guidolin, L.; Binelli, S.; Canafoglia, L.; Sartori, L.; Garofalo, P.; Pozzi, F.; Silenzi, V.; Bertelletti, D.; Di Fazio, M.; Perucca, E.

In: Bollettino - Lega Italiana contro l'Epilessia, No. 99, 1997, p. 105-107.

Research output: Contribution to journal › Article › peer-review

Canger, R, Avanzini, G, Tartara, A, Durisotti, C, Guidolin, L, Binelli, S , Canafoglia, L, Sartori, L, Garofalo, P, Pozzi, F, Silenzi, V, Bertelletti, D, Di Fazio, M & Perucca, E 1997, 'Efficacia e tollerabilita del Topiramato nella terapia aggiuntiva a lungo termine: Analisi ad interim dopo quattro anni di trattamento', Bollettino - Lega Italiana contro l'Epilessia, no. 99, pp. 105-107.

Canger, R. ; Avanzini, G. ; Tartara, A. ; Durisotti, C. ; Guidolin, L. ; Binelli, S. ; Canafoglia, L. ; Sartori, L. ; Garofalo, P. ; Pozzi, F. ; Silenzi, V. ; Bertelletti, D. ; Di Fazio, M. ; Perucca, E. / Efficacia e tollerabilita del Topiramato nella terapia aggiuntiva a lungo termine : Analisi ad interim dopo quattro anni di trattamento. In: Bollettino - Lega Italiana contro l'Epilessia. 1997 ; No. 99. pp. 105-107.

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abstract = "In this open trial efficacy and tolerability of topiramate add-on long term administration have been evaluted in patients with uncontrolled epilepsy of any seizure type 67 patients from 4 Italian centres were studied. TPM was added-on four standard AED's. After TPM titration, a maintenance period with the optimal efficacy dose has been reached in 64 patients. After 3 years, the mean duration of treatment was 9,5 months (± 7,6 d.s), the mean dose of TPM was 274 (± 144) mg/day. The reduction of seizure frequency was obteined in 30% of patients; 75% reduction occurred in 14% and 8% was seizure-free. 19,4% of patients dropped-out for adverse events, 22,4% for inefficacy.",

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author = "R. Canger and G. Avanzini and A. Tartara and C. Durisotti and L. Guidolin and S. Binelli and L. Canafoglia and L. Sartori and P. Garofalo and F. Pozzi and V. Silenzi and D. Bertelletti and {Di Fazio}, M. and E. Perucca",

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T2 - Analisi ad interim dopo quattro anni di trattamento

AU - Canger, R.

AU - Avanzini, G.

AU - Tartara, A.

AU - Durisotti, C.

AU - Guidolin, L.

AU - Binelli, S.

AU - Canafoglia, L.

AU - Sartori, L.

AU - Garofalo, P.

AU - Pozzi, F.

AU - Silenzi, V.

AU - Bertelletti, D.

AU - Di Fazio, M.

AU - Perucca, E.

PY - 1997

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AB - In this open trial efficacy and tolerability of topiramate add-on long term administration have been evaluted in patients with uncontrolled epilepsy of any seizure type 67 patients from 4 Italian centres were studied. TPM was added-on four standard AED's. After TPM titration, a maintenance period with the optimal efficacy dose has been reached in 64 patients. After 3 years, the mean duration of treatment was 9,5 months (± 7,6 d.s), the mean dose of TPM was 274 (± 144) mg/day. The reduction of seizure frequency was obteined in 30% of patients; 75% reduction occurred in 14% and 8% was seizure-free. 19,4% of patients dropped-out for adverse events, 22,4% for inefficacy.

KW - Antiepileptic drugs

KW - Epilepsy

KW - Seizures

KW - Topiramate

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