Long-term efficacy of Narivent® in the treatment of nasal congestion

Valerio Damiani, Angelo Camaioni, Claudio Viti, Giulia Schillani, Francesca Foltran, Antonella Silvia Scirè, Giada Morpurgo, Dario Gregori

Research output: Contribution to journalArticlepeer-review


Rationale and aim: Nasal congestion is a common symptom in allergic and non-allergic rhinitis, rhinosinusitis and nasal polyposis. Although various pharmacotherapy options exist, no agent is universally efficacious. The aim of this study was to evaluate the clinical effectiveness efficacy of Narivent®, which is an osmotically acting medical device with anti-oedematous and anti-inflammatory effects, in a long-term (30 days) treatment. Methods: A single-centre prospective study with a pre-post design was conducted with consecutive enrolment in an Italian Otolaryngology Department of 56 both genders patients with persistent nasal congestion. Patients received 2 puffs of Narivent® into each nostril 2 times a day over the course of 4 weeks. The severity of symptoms was assessed subjectively as measured by a 0 to 10 visual analogue scale (VAS) and the presence/absence of symptoms and signs. Differences in subjective and objective severity measures before and after treatment were compared using Paired-Sample Wilcoxon Signed Rank Test. Results: A significant improvement after treatment (p

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalOpen Medical Devices Journal
Issue numberSPL. ISS.
Publication statusPublished - 2012


  • Anti-inflammatory activity
  • Anti-oedematous activity
  • Osmotically acting medical device
  • Persistent nasal congestion

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)


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