Long term evaluation of gas exchange and hydrodynamic performance of a heparinized artificial lung: Comparison of two different hollow fiber pore sizes

S. Crotti, D. Tubiolo, P. Pelosi, D. Chiumello, D. Mascheroni, L. Gattinoni

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the performance of a heparinized hollow fiber artificial lung (Medtronic, Minimax) featuring standard hollow fibers (Group A) and experimental hollow fibers with a smaller pore size (Group B). Four sheep in each group underwent a veno-venous bypass for 72 hours. Every 6 hours, at 3 different blood flow rates (BFr) (400, 800, 1200 ml/min), at a constant gas flow rate (Gfr = 4 L/min), and at a constant blood inlet PCO2 (45-55 mmHg), we measured the oxygenation performance (O2 transfer = VO2 and blood outlet PO2 = PO2 out), CO2 removal (CO2 transfer = VCO2 and PCO2 outlet = PCO2(out)) and pressure drop across the device (ΔP). A total of about 50 measurement sets were obtained for each group at different time points and blood flow rates. Both groups showed a good oxygenation performance (PO2(out) always higher than 200 mmHg) and no differences were observed between the two groups (at 1200 ml/min BFr, the average VO2 of all time points was 47 ± 15 ml/min in group A and 44 ± 11 ml/min in group B, mean ± SD, NS). During the first 24 hours, the VCO2 was higher in Group B than in Group A at each BFr (at 1200 ml/min BFr, 81 ± 18 vs 67 ± 20 ml/min, p <0.01), while no differences were observed during the subsequent 48 hours. Throughout the entire experiment, VCO2 increased with increasing BFr in both groups, (in group B, from 43 ± 14 ml/min at 400 ml/min BFr, to 73 ± 17 ml/min at 1200 ml/min BFr, average of all time points, p <0.01). In both groups the ΔP increased with the increasing BFr, but it was lower in Group B than in Group A at BFr 800 and 1200 ml/min (at 1200 ml/min BFr, 51 ± 15 mmHg vs 65 ± 17 mmHg, p <0.01), and remained stable for the entire experimental period.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalInternational Journal of Artificial Organs
Volume20
Issue number1
Publication statusPublished - Jan 1997

Keywords

  • artificial lung
  • extracorporeal circulation
  • hollow fibers
  • pore size

ASJC Scopus subject areas

  • Biophysics

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