Long-term evaluation of human umbilical vein as small-caliber arterial substitute

G. Motta, G. B. Ratto, A. Sacco

Research output: Contribution to journalArticlepeer-review

Abstract

Since 1977, 61 arterial reconstructions using glutaraldehyde-tanned human umbilical vein (HUV) grafts were carried out in 56 patients (51 males, 5 females) with unsuitable autogenous saphenous vein. Their mean age was 69 ± 14 years. Limb salvage was the primary indication for surgery. HUV grafts were used to perform 44 femoropopliteal, 4 composite aortopopliteal (with a direct end-to-end anastomosis between an aortofemoral Dacron graft and a femoropopliteal HUV graft), 5 femorotibial, and 6 axillofemoral bypasses, and 1 femorofemoral and 1 iliopopliteal bypass. Ten-year cumulative patency rates were 31% for all HUV reconstructions, 36% for femoropopliteal bypasses, and 32% for femoropopliteal bypasses carried out for limb salvage only. Four of the 5 femorotibial reconstructions failed during the first month following surgery. Two of the 6 axillofemoral and 3 of the 4 composite aortopopliteal bypasses thrombosed within one and three years after surgery respectively. In conclusion, the study evidenced long-term durability of HUV grafts, supporting their use for femorodistal reconstructions in patients with limb-threatening ischemia and inadequate autogenous saphenous vein.

Original languageEnglish
Pages (from-to)328-334
Number of pages7
JournalVascular Surgery
Volume22
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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