Abstract
We retrospectively evaluated 143 first renal transplant recipients (120 from cadavers and 23 from living donors) receiving CsA monotherapy. The effects of both basal and time-dependent variables on 11-year graft survival were evaluated by Cox's analysis. Shifted patients were compared to the whole transplant population by means of 'landmark method' and Simon and Makuch's graphical representation. Graft half-life was calculated according to Cho and Terasaki. The mean follow-up was 85.8 months. Thirty-four percent of the patients remained on the original CsA monotherapy, while in the remaining 64% steroids had to be added. Cumulative patient and graft survival at 11 years were 0.89 and 0.62. Cumulative graft half-life was 19.98 years. By multivariate analysis, basal variables which correlated with a worse 11-year graft survival were: >45 months spent on dialysis (RR 3.17; p=0.001), no blood transfusion prior to transplantation (RR 2.58; p=0.008), CsA administration in a double daily dose (RR 2.13; p=0.018) and a transplant from a cadaver donor (RR 4. 72; p=0.032). In addition, Cox's analysis of time-dependent variables showed that delayed graft function recovery, (RR 2.43; p=0.007) and the need of adding steroids and/or azathioprine (RR 3.68; p
| Original language | Italian |
|---|---|
| Pages (from-to) | 186-192 |
| Number of pages | 7 |
| Journal | Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia |
| Volume | 16 |
| Issue number | 2 |
| Publication status | Published - 1999 |
Fingerprint
ASJC Scopus subject areas
- Nephrology
Cite this
Valutazione a lungo termine della conversione da monoterapia con ciclosporina a duplice o triplice terapia nel trapianto renale. / Montagnino, G.; Tarantino, A.; Maccario, M.; Cesana, B.; Elli, A.; Ponticelli, C.
In: Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, Vol. 16, No. 2, 1999, p. 186-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Valutazione a lungo termine della conversione da monoterapia con ciclosporina a duplice o triplice terapia nel trapianto renale
AU - Montagnino, G.
AU - Tarantino, A.
AU - Maccario, M.
AU - Cesana, B.
AU - Elli, A.
AU - Ponticelli, C.
PY - 1999
Y1 - 1999
N2 - We retrospectively evaluated 143 first renal transplant recipients (120 from cadavers and 23 from living donors) receiving CsA monotherapy. The effects of both basal and time-dependent variables on 11-year graft survival were evaluated by Cox's analysis. Shifted patients were compared to the whole transplant population by means of 'landmark method' and Simon and Makuch's graphical representation. Graft half-life was calculated according to Cho and Terasaki. The mean follow-up was 85.8 months. Thirty-four percent of the patients remained on the original CsA monotherapy, while in the remaining 64% steroids had to be added. Cumulative patient and graft survival at 11 years were 0.89 and 0.62. Cumulative graft half-life was 19.98 years. By multivariate analysis, basal variables which correlated with a worse 11-year graft survival were: >45 months spent on dialysis (RR 3.17; p=0.001), no blood transfusion prior to transplantation (RR 2.58; p=0.008), CsA administration in a double daily dose (RR 2.13; p=0.018) and a transplant from a cadaver donor (RR 4. 72; p=0.032). In addition, Cox's analysis of time-dependent variables showed that delayed graft function recovery, (RR 2.43; p=0.007) and the need of adding steroids and/or azathioprine (RR 3.68; p
AB - We retrospectively evaluated 143 first renal transplant recipients (120 from cadavers and 23 from living donors) receiving CsA monotherapy. The effects of both basal and time-dependent variables on 11-year graft survival were evaluated by Cox's analysis. Shifted patients were compared to the whole transplant population by means of 'landmark method' and Simon and Makuch's graphical representation. Graft half-life was calculated according to Cho and Terasaki. The mean follow-up was 85.8 months. Thirty-four percent of the patients remained on the original CsA monotherapy, while in the remaining 64% steroids had to be added. Cumulative patient and graft survival at 11 years were 0.89 and 0.62. Cumulative graft half-life was 19.98 years. By multivariate analysis, basal variables which correlated with a worse 11-year graft survival were: >45 months spent on dialysis (RR 3.17; p=0.001), no blood transfusion prior to transplantation (RR 2.58; p=0.008), CsA administration in a double daily dose (RR 2.13; p=0.018) and a transplant from a cadaver donor (RR 4. 72; p=0.032). In addition, Cox's analysis of time-dependent variables showed that delayed graft function recovery, (RR 2.43; p=0.007) and the need of adding steroids and/or azathioprine (RR 3.68; p
KW - CsA monotherapy
KW - Kidney transplantation
KW - Long-term evaluation
KW - Multivariate analysis
KW - Therapeutic conversion
UR - http://www.scopus.com/inward/record.url?scp=0032721386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032721386&partnerID=8YFLogxK
M3 - Articolo
VL - 16
SP - 186
EP - 192
JO - Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
JF - Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
SN - 0393-5590
IS - 2
ER -