Valutazione a lungo termine della conversione da monoterapia con ciclosporina a duplice o triplice terapia nel trapianto renale

Translated title of the contribution: Long-term evaluation of therapeutic conversion from cyclosporine monotherapy to double or triple therapy in renal transplantation

G. Montagnino, A. Tarantino, M. Maccario, B. Cesana, A. Elli, C. Ponticelli

Research output: Contribution to journalArticle

Abstract

We retrospectively evaluated 143 first renal transplant recipients (120 from cadavers and 23 from living donors) receiving CsA monotherapy. The effects of both basal and time-dependent variables on 11-year graft survival were evaluated by Cox's analysis. Shifted patients were compared to the whole transplant population by means of 'landmark method' and Simon and Makuch's graphical representation. Graft half-life was calculated according to Cho and Terasaki. The mean follow-up was 85.8 months. Thirty-four percent of the patients remained on the original CsA monotherapy, while in the remaining 64% steroids had to be added. Cumulative patient and graft survival at 11 years were 0.89 and 0.62. Cumulative graft half-life was 19.98 years. By multivariate analysis, basal variables which correlated with a worse 11-year graft survival were: >45 months spent on dialysis (RR 3.17; p=0.001), no blood transfusion prior to transplantation (RR 2.58; p=0.008), CsA administration in a double daily dose (RR 2.13; p=0.018) and a transplant from a cadaver donor (RR 4. 72; p=0.032). In addition, Cox's analysis of time-dependent variables showed that delayed graft function recovery, (RR 2.43; p=0.007) and the need of adding steroids and/or azathioprine (RR 3.68; p

Translated title of the contributionLong-term evaluation of therapeutic conversion from cyclosporine monotherapy to double or triple therapy in renal transplantation
Original languageItalian
Pages (from-to)186-192
Number of pages7
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume16
Issue number2
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Nephrology

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