Abstract
We retrospectively evaluated 143 first renal transplant recipients (120 from cadavers and 23 from living donors) receiving CsA monotherapy. The effects of both basal and time-dependent variables on 11-year graft survival were evaluated by Cox's analysis. Shifted patients were compared to the whole transplant population by means of 'landmark method' and Simon and Makuch's graphical representation. Graft half-life was calculated according to Cho and Terasaki. The mean follow-up was 85.8 months. Thirty-four percent of the patients remained on the original CsA monotherapy, while in the remaining 64% steroids had to be added. Cumulative patient and graft survival at 11 years were 0.89 and 0.62. Cumulative graft half-life was 19.98 years. By multivariate analysis, basal variables which correlated with a worse 11-year graft survival were: >45 months spent on dialysis (RR 3.17; p=0.001), no blood transfusion prior to transplantation (RR 2.58; p=0.008), CsA administration in a double daily dose (RR 2.13; p=0.018) and a transplant from a cadaver donor (RR 4. 72; p=0.032). In addition, Cox's analysis of time-dependent variables showed that delayed graft function recovery, (RR 2.43; p=0.007) and the need of adding steroids and/or azathioprine (RR 3.68; p
Translated title of the contribution | Long-term evaluation of therapeutic conversion from cyclosporine monotherapy to double or triple therapy in renal transplantation |
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Original language | Italian |
Pages (from-to) | 186-192 |
Number of pages | 7 |
Journal | Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia |
Volume | 16 |
Issue number | 2 |
Publication status | Published - 1999 |
ASJC Scopus subject areas
- Nephrology