STUDIO CLINICO A LUNGO TERMINE DEL VIGABATRIN NELL'EPILESSIA FARMACORESISTENTE

Translated title of the contribution: Long-term evaluation of vigabatrin for refractory epilepsy

R. Michelucci, A. Forti, G. Rubboli, R. Plasmati, F. Salvi, P. Zonari, M. Zamagni, A. Iudice, J. P. Mumford, C. A. Tassinari

Research output: Contribution to journalArticle

Abstract

Twenty-four adult drug-resistant epileptic patients who had shown a satisfactory clinical response to add-on vigabatrin under placebo-controlled conditions continued on long-term treatment. Out of the 24 patients included in the study, 17 were still on vigabatrin after a mean period of 37 months. In these patients, the reduction in seizure frequency was statistically significant at each assessable time of observation during long-term treatment as compared with the baseline period. Tolerance to vigabatrin was good and no patient was withdrawn because of side effects. Serum levels of phenytoin were significantly reduced during vigabatrin treatment.

Translated title of the contributionLong-term evaluation of vigabatrin for refractory epilepsy
Original languageItalian
Pages (from-to)129-130
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number70-71
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Michelucci, R., Forti, A., Rubboli, G., Plasmati, R., Salvi, F., Zonari, P., Zamagni, M., Iudice, A., Mumford, J. P., & Tassinari, C. A. (1990). STUDIO CLINICO A LUNGO TERMINE DEL VIGABATRIN NELL'EPILESSIA FARMACORESISTENTE. Bollettino - Lega Italiana contro l'Epilessia, (70-71), 129-130.