Twenty-four adult drug-resistant epileptic patients who had shown a satisfactory clinical response to add-on vigabatrin under placebo-controlled conditions continued on long-term treatment. Out of the 24 patients included in the study, 17 were still on vigabatrin after a mean period of 37 months. In these patients, the reduction in seizure frequency was statistically significant at each assessable time of observation during long-term treatment as compared with the baseline period. Tolerance to vigabatrin was good and no patient was withdrawn because of side effects. Serum levels of phenytoin were significantly reduced during vigabatrin treatment.
|Translated title of the contribution||Long-term evaluation of vigabatrin for refractory epilepsy|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Clinical Neurology