Long-term evolution after in-hospital cardiac arrest in children: Prospective multicenter multinational study

Jimena del Castillo, Jesús López-Herce, Martha Matamoros, Sonia Cañadas, Ana Rodríguez-Calvo, Corrado Cecchetti, Antonio Rodriguez-Núñez, Angel Carrillo Álvarez, Javier Urbano, Angel Carrillo, JoseMaría Bellón, Pedro Dominguez, Roger Rodriguez, Allison Callejas, Douglas Carranza, Hilda Zerón, Lorenzo Marcos, Marta Silva, Regina Grigolli Cesar, Javier Pilar OriveAna María Nieva, Antonio Rodríguez-Núñez, Marta Parada, María AngelesGarcía Teresa, Jessica Ortiz Rodriguez, Di Prietro Pasquale, Miguel Angel Delgado, Pedro Pablo Oyágüez Ugidos, Roxana Flavia Jaén, Juan Garbayo Solana, Raúl Borrego Domínguez, Víctor Monreal, Custodio Calvo, Concepción Goñi Orayen, Iolster Thomas, Ricardo Iramaín, Juan Carlos de Carlos, Corsino Rey Galán, Olivia Pérez Quevedo, Santiago Campos, Sivia Sánchez Pérez, Deolinda Matos, Isabel Lucía Benítez Gómez, Santiago Hermógenes Esquivel, Cecilia Andrea Chede, Gabriel Cassaletti Bustillo

Research output: Contribution to journalArticlepeer-review


Objective: The main objective was to study survival and neurologic evolution of children who suffered in-hospital pediatric cardiac arrest (CA). The secondary objective was to analyze the influence of risk factors on the long term outcome after CA. Methods: prospective, international, observational, multicentric study in 48 hospitals of 12 countries. CA in children between 1 month and 18 years were analyzed using the Utstein template. Survival and neurological state measured by Pediatric Cerebral Performance Category (PCPC) scale one year after hospital discharge was evaluated. Results: 502 patients with in-hospital CA were evaluated. 197 of them (39.2%) survived to hospital discharge. PCPC at hospital discharge was available in 156 of survivors (79.2%). 76.9% had good neurologic state (PCPC 1-2) and 23.1% poor PCPC values (3-6). One year after cardiac arrest we could obtain data from 144 patients (28.6%). PCPC was available in 116 patients. 88 (75.9%) had a good neurologic evaluation and 28 (24.1%) a poor one. A neurological deterioration evaluated by PCPC scale was observed in 40 patients (7.9%). One year after cardiac arrest PCPC scores compared to hospital discharge had worsen in 7 patients (6%), remained constant in 103 patients (88.8%) and had improved in 6 patients (5.2%). Conclusion: Survival one year after cardiac arrest in children after in-hospital cardiac arrest is high. Neurologic outcome of these children a year after cardiac arrest is mostly the same as after hospital discharge. The factors associated with a worst long-term neurological outcome are the etiology of arrest being a traumatic or neurologic illness, and the persistency of higher lactic acid values 24. h after ROSC. A standardised basic protocol even practicable for lower developed countries would be a first step for the new multicenter studies.

Original languageEnglish
Pages (from-to)126-134
Number of pages9
Publication statusPublished - Nov 1 2015


  • Cardiac arrest
  • Children
  • In-hospital cardiac arrest
  • Long-term outcome
  • Resuscitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine


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