Long-term evolution after in-hospital cardiac arrest in children: Prospective multicenter multinational study

Jimena del Castillo, Jesús López-Herce, Martha Matamoros, Sonia Cañadas, Ana Rodríguez-Calvo, Corrado Cecchetti, Antonio Rodriguez-Núñez, Angel Carrillo Álvarez, Javier Urbano, Angel Carrillo, JoseMaría Bellón, Pedro Dominguez, Roger Rodriguez, Allison Callejas, Douglas Carranza, Hilda Zerón, Lorenzo Marcos, Marta Silva, Regina Grigolli Cesar, Javier Pilar OriveAna María Nieva, Antonio Rodríguez-Núñez, Marta Parada, María AngelesGarcía Teresa, Jessica Ortiz Rodriguez, Di Prietro Pasquale, Miguel Angel Delgado, Pedro Pablo Oyágüez Ugidos, Roxana Flavia Jaén, Juan Garbayo Solana, Raúl Borrego Domínguez, Víctor Monreal, Custodio Calvo, Concepción Goñi Orayen, Iolster Thomas, Ricardo Iramaín, Juan Carlos de Carlos, Corsino Rey Galán, Olivia Pérez Quevedo, Santiago Campos, Sivia Sánchez Pérez, Deolinda Matos, Isabel Lucía Benítez Gómez, Santiago Hermógenes Esquivel, Cecilia Andrea Chede, Gabriel Cassaletti Bustillo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: The main objective was to study survival and neurologic evolution of children who suffered in-hospital pediatric cardiac arrest (CA). The secondary objective was to analyze the influence of risk factors on the long term outcome after CA. Methods: prospective, international, observational, multicentric study in 48 hospitals of 12 countries. CA in children between 1 month and 18 years were analyzed using the Utstein template. Survival and neurological state measured by Pediatric Cerebral Performance Category (PCPC) scale one year after hospital discharge was evaluated. Results: 502 patients with in-hospital CA were evaluated. 197 of them (39.2%) survived to hospital discharge. PCPC at hospital discharge was available in 156 of survivors (79.2%). 76.9% had good neurologic state (PCPC 1-2) and 23.1% poor PCPC values (3-6). One year after cardiac arrest we could obtain data from 144 patients (28.6%). PCPC was available in 116 patients. 88 (75.9%) had a good neurologic evaluation and 28 (24.1%) a poor one. A neurological deterioration evaluated by PCPC scale was observed in 40 patients (7.9%). One year after cardiac arrest PCPC scores compared to hospital discharge had worsen in 7 patients (6%), remained constant in 103 patients (88.8%) and had improved in 6 patients (5.2%). Conclusion: Survival one year after cardiac arrest in children after in-hospital cardiac arrest is high. Neurologic outcome of these children a year after cardiac arrest is mostly the same as after hospital discharge. The factors associated with a worst long-term neurological outcome are the etiology of arrest being a traumatic or neurologic illness, and the persistency of higher lactic acid values 24. h after ROSC. A standardised basic protocol even practicable for lower developed countries would be a first step for the new multicenter studies.

Original languageEnglish
Pages (from-to)126-134
Number of pages9
JournalResuscitation
Volume96
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Heart Arrest
Multicenter Studies
Pediatrics
Nervous System
Survival
Pediatric Hospitals
Developed Countries
Observational Studies
Survivors
Lactic Acid

Keywords

  • Cardiac arrest
  • Children
  • In-hospital cardiac arrest
  • Long-term outcome
  • Resuscitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine

Cite this

del Castillo, J., López-Herce, J., Matamoros, M., Cañadas, S., Rodríguez-Calvo, A., Cecchetti, C., ... Bustillo, G. C. (2015). Long-term evolution after in-hospital cardiac arrest in children: Prospective multicenter multinational study. Resuscitation, 96, 126-134. https://doi.org/10.1016/j.resuscitation.2015.07.037

Long-term evolution after in-hospital cardiac arrest in children : Prospective multicenter multinational study. / del Castillo, Jimena; López-Herce, Jesús; Matamoros, Martha; Cañadas, Sonia; Rodríguez-Calvo, Ana; Cecchetti, Corrado; Rodriguez-Núñez, Antonio; Álvarez, Angel Carrillo; Urbano, Javier; Carrillo, Angel; Bellón, JoseMaría; Dominguez, Pedro; Rodriguez, Roger; Callejas, Allison; Carranza, Douglas; Zerón, Hilda; Marcos, Lorenzo; Silva, Marta; Cesar, Regina Grigolli; Orive, Javier Pilar; Nieva, Ana María; Rodríguez-Núñez, Antonio; Parada, Marta; Teresa, María AngelesGarcía; Rodriguez, Jessica Ortiz; Pasquale, Di Prietro; Delgado, Miguel Angel; Ugidos, Pedro Pablo Oyágüez; Jaén, Roxana Flavia; Solana, Juan Garbayo; Domínguez, Raúl Borrego; Monreal, Víctor; Calvo, Custodio; Orayen, Concepción Goñi; Thomas, Iolster; Iramaín, Ricardo; de Carlos, Juan Carlos; Galán, Corsino Rey; Quevedo, Olivia Pérez; Campos, Santiago; Pérez, Sivia Sánchez; Matos, Deolinda; Gómez, Isabel Lucía Benítez; Esquivel, Santiago Hermógenes; Chede, Cecilia Andrea; Bustillo, Gabriel Cassaletti.

In: Resuscitation, Vol. 96, 01.11.2015, p. 126-134.

Research output: Contribution to journalArticle

del Castillo, J, López-Herce, J, Matamoros, M, Cañadas, S, Rodríguez-Calvo, A, Cecchetti, C, Rodriguez-Núñez, A, Álvarez, AC, Urbano, J, Carrillo, A, Bellón, J, Dominguez, P, Rodriguez, R, Callejas, A, Carranza, D, Zerón, H, Marcos, L, Silva, M, Cesar, RG, Orive, JP, Nieva, AM, Rodríguez-Núñez, A, Parada, M, Teresa, MA, Rodriguez, JO, Pasquale, DP, Delgado, MA, Ugidos, PPO, Jaén, RF, Solana, JG, Domínguez, RB, Monreal, V, Calvo, C, Orayen, CG, Thomas, I, Iramaín, R, de Carlos, JC, Galán, CR, Quevedo, OP, Campos, S, Pérez, SS, Matos, D, Gómez, ILB, Esquivel, SH, Chede, CA & Bustillo, GC 2015, 'Long-term evolution after in-hospital cardiac arrest in children: Prospective multicenter multinational study', Resuscitation, vol. 96, pp. 126-134. https://doi.org/10.1016/j.resuscitation.2015.07.037
del Castillo, Jimena ; López-Herce, Jesús ; Matamoros, Martha ; Cañadas, Sonia ; Rodríguez-Calvo, Ana ; Cecchetti, Corrado ; Rodriguez-Núñez, Antonio ; Álvarez, Angel Carrillo ; Urbano, Javier ; Carrillo, Angel ; Bellón, JoseMaría ; Dominguez, Pedro ; Rodriguez, Roger ; Callejas, Allison ; Carranza, Douglas ; Zerón, Hilda ; Marcos, Lorenzo ; Silva, Marta ; Cesar, Regina Grigolli ; Orive, Javier Pilar ; Nieva, Ana María ; Rodríguez-Núñez, Antonio ; Parada, Marta ; Teresa, María AngelesGarcía ; Rodriguez, Jessica Ortiz ; Pasquale, Di Prietro ; Delgado, Miguel Angel ; Ugidos, Pedro Pablo Oyágüez ; Jaén, Roxana Flavia ; Solana, Juan Garbayo ; Domínguez, Raúl Borrego ; Monreal, Víctor ; Calvo, Custodio ; Orayen, Concepción Goñi ; Thomas, Iolster ; Iramaín, Ricardo ; de Carlos, Juan Carlos ; Galán, Corsino Rey ; Quevedo, Olivia Pérez ; Campos, Santiago ; Pérez, Sivia Sánchez ; Matos, Deolinda ; Gómez, Isabel Lucía Benítez ; Esquivel, Santiago Hermógenes ; Chede, Cecilia Andrea ; Bustillo, Gabriel Cassaletti. / Long-term evolution after in-hospital cardiac arrest in children : Prospective multicenter multinational study. In: Resuscitation. 2015 ; Vol. 96. pp. 126-134.
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abstract = "Objective: The main objective was to study survival and neurologic evolution of children who suffered in-hospital pediatric cardiac arrest (CA). The secondary objective was to analyze the influence of risk factors on the long term outcome after CA. Methods: prospective, international, observational, multicentric study in 48 hospitals of 12 countries. CA in children between 1 month and 18 years were analyzed using the Utstein template. Survival and neurological state measured by Pediatric Cerebral Performance Category (PCPC) scale one year after hospital discharge was evaluated. Results: 502 patients with in-hospital CA were evaluated. 197 of them (39.2{\%}) survived to hospital discharge. PCPC at hospital discharge was available in 156 of survivors (79.2{\%}). 76.9{\%} had good neurologic state (PCPC 1-2) and 23.1{\%} poor PCPC values (3-6). One year after cardiac arrest we could obtain data from 144 patients (28.6{\%}). PCPC was available in 116 patients. 88 (75.9{\%}) had a good neurologic evaluation and 28 (24.1{\%}) a poor one. A neurological deterioration evaluated by PCPC scale was observed in 40 patients (7.9{\%}). One year after cardiac arrest PCPC scores compared to hospital discharge had worsen in 7 patients (6{\%}), remained constant in 103 patients (88.8{\%}) and had improved in 6 patients (5.2{\%}). Conclusion: Survival one year after cardiac arrest in children after in-hospital cardiac arrest is high. Neurologic outcome of these children a year after cardiac arrest is mostly the same as after hospital discharge. The factors associated with a worst long-term neurological outcome are the etiology of arrest being a traumatic or neurologic illness, and the persistency of higher lactic acid values 24. h after ROSC. A standardised basic protocol even practicable for lower developed countries would be a first step for the new multicenter studies.",
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T1 - Long-term evolution after in-hospital cardiac arrest in children

T2 - Prospective multicenter multinational study

AU - del Castillo, Jimena

AU - López-Herce, Jesús

AU - Matamoros, Martha

AU - Cañadas, Sonia

AU - Rodríguez-Calvo, Ana

AU - Cecchetti, Corrado

AU - Rodriguez-Núñez, Antonio

AU - Álvarez, Angel Carrillo

AU - Urbano, Javier

AU - Carrillo, Angel

AU - Bellón, JoseMaría

AU - Dominguez, Pedro

AU - Rodriguez, Roger

AU - Callejas, Allison

AU - Carranza, Douglas

AU - Zerón, Hilda

AU - Marcos, Lorenzo

AU - Silva, Marta

AU - Cesar, Regina Grigolli

AU - Orive, Javier Pilar

AU - Nieva, Ana María

AU - Rodríguez-Núñez, Antonio

AU - Parada, Marta

AU - Teresa, María AngelesGarcía

AU - Rodriguez, Jessica Ortiz

AU - Pasquale, Di Prietro

AU - Delgado, Miguel Angel

AU - Ugidos, Pedro Pablo Oyágüez

AU - Jaén, Roxana Flavia

AU - Solana, Juan Garbayo

AU - Domínguez, Raúl Borrego

AU - Monreal, Víctor

AU - Calvo, Custodio

AU - Orayen, Concepción Goñi

AU - Thomas, Iolster

AU - Iramaín, Ricardo

AU - de Carlos, Juan Carlos

AU - Galán, Corsino Rey

AU - Quevedo, Olivia Pérez

AU - Campos, Santiago

AU - Pérez, Sivia Sánchez

AU - Matos, Deolinda

AU - Gómez, Isabel Lucía Benítez

AU - Esquivel, Santiago Hermógenes

AU - Chede, Cecilia Andrea

AU - Bustillo, Gabriel Cassaletti

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Objective: The main objective was to study survival and neurologic evolution of children who suffered in-hospital pediatric cardiac arrest (CA). The secondary objective was to analyze the influence of risk factors on the long term outcome after CA. Methods: prospective, international, observational, multicentric study in 48 hospitals of 12 countries. CA in children between 1 month and 18 years were analyzed using the Utstein template. Survival and neurological state measured by Pediatric Cerebral Performance Category (PCPC) scale one year after hospital discharge was evaluated. Results: 502 patients with in-hospital CA were evaluated. 197 of them (39.2%) survived to hospital discharge. PCPC at hospital discharge was available in 156 of survivors (79.2%). 76.9% had good neurologic state (PCPC 1-2) and 23.1% poor PCPC values (3-6). One year after cardiac arrest we could obtain data from 144 patients (28.6%). PCPC was available in 116 patients. 88 (75.9%) had a good neurologic evaluation and 28 (24.1%) a poor one. A neurological deterioration evaluated by PCPC scale was observed in 40 patients (7.9%). One year after cardiac arrest PCPC scores compared to hospital discharge had worsen in 7 patients (6%), remained constant in 103 patients (88.8%) and had improved in 6 patients (5.2%). Conclusion: Survival one year after cardiac arrest in children after in-hospital cardiac arrest is high. Neurologic outcome of these children a year after cardiac arrest is mostly the same as after hospital discharge. The factors associated with a worst long-term neurological outcome are the etiology of arrest being a traumatic or neurologic illness, and the persistency of higher lactic acid values 24. h after ROSC. A standardised basic protocol even practicable for lower developed countries would be a first step for the new multicenter studies.

AB - Objective: The main objective was to study survival and neurologic evolution of children who suffered in-hospital pediatric cardiac arrest (CA). The secondary objective was to analyze the influence of risk factors on the long term outcome after CA. Methods: prospective, international, observational, multicentric study in 48 hospitals of 12 countries. CA in children between 1 month and 18 years were analyzed using the Utstein template. Survival and neurological state measured by Pediatric Cerebral Performance Category (PCPC) scale one year after hospital discharge was evaluated. Results: 502 patients with in-hospital CA were evaluated. 197 of them (39.2%) survived to hospital discharge. PCPC at hospital discharge was available in 156 of survivors (79.2%). 76.9% had good neurologic state (PCPC 1-2) and 23.1% poor PCPC values (3-6). One year after cardiac arrest we could obtain data from 144 patients (28.6%). PCPC was available in 116 patients. 88 (75.9%) had a good neurologic evaluation and 28 (24.1%) a poor one. A neurological deterioration evaluated by PCPC scale was observed in 40 patients (7.9%). One year after cardiac arrest PCPC scores compared to hospital discharge had worsen in 7 patients (6%), remained constant in 103 patients (88.8%) and had improved in 6 patients (5.2%). Conclusion: Survival one year after cardiac arrest in children after in-hospital cardiac arrest is high. Neurologic outcome of these children a year after cardiac arrest is mostly the same as after hospital discharge. The factors associated with a worst long-term neurological outcome are the etiology of arrest being a traumatic or neurologic illness, and the persistency of higher lactic acid values 24. h after ROSC. A standardised basic protocol even practicable for lower developed countries would be a first step for the new multicenter studies.

KW - Cardiac arrest

KW - Children

KW - In-hospital cardiac arrest

KW - Long-term outcome

KW - Resuscitation

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