Long-term evolution of neuropsychological competences in encephalopathy with status epilepticus during sleep

A variable prognosis

Maria C. Pera, Daniela Brazzo, Nausicaa Altieri, Umberto Balottin, Pierangelo Veggiotti

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: The aim of this study was to evaluate the long-term cognitive outcome in children with continuous spikes and waves during slow wave sleep (CSWSsyndrome). Methods: We reviewed the neuropsychological tests of 25 children diagnosed with CSWS between 1987 and 2010 and with a mean follow-up of 13.5 years. Key Findings: Cognitive performances worsened during CSWS in virtually all patients. Seven patients (28%) with nonlesional epilepsy had a positive outcome; three patients (12%) showed persistence of motor deficit without involvement of cognitive functions; and seven patients (28%) who presented a long duration of CSWS (mean = 28.1 months) had a negative cognitive outcome. In 6 patients (24%) with structural or metabolic disorders before CSWS onset cognitive outcomes did not change; 2 patients (8%) had a negative outcome irrespective of the duration or presence of other neurologic disorders before CSWS onset. Forty-four percent of children with CSWS demonstrated permanent cognitive impairment. Significance: The long-term outcome of CSWS syndrome is variable and seems to depend on treatment response, disease duration, and underlying etiology. Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalEpilepsia
Volume54
Issue numberSUPPL.7
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Status Epilepticus
Brain Diseases
Mental Competency
Sleep
Neuropsychological Tests
Nervous System Diseases
Cognition
Epilepsy

Keywords

  • CSWS
  • Epilepsy
  • ESES
  • Neuropsychological evaluation
  • Outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Long-term evolution of neuropsychological competences in encephalopathy with status epilepticus during sleep : A variable prognosis. / Pera, Maria C.; Brazzo, Daniela; Altieri, Nausicaa; Balottin, Umberto; Veggiotti, Pierangelo.

In: Epilepsia, Vol. 54, No. SUPPL.7, 10.2013, p. 77-85.

Research output: Contribution to journalArticle

Pera, Maria C. ; Brazzo, Daniela ; Altieri, Nausicaa ; Balottin, Umberto ; Veggiotti, Pierangelo. / Long-term evolution of neuropsychological competences in encephalopathy with status epilepticus during sleep : A variable prognosis. In: Epilepsia. 2013 ; Vol. 54, No. SUPPL.7. pp. 77-85.
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