Long-term evolution of neuropsychological competences in encephalopathy with status epilepticus during sleep: A variable prognosis

Maria C. Pera, Daniela Brazzo, Nausicaa Altieri, Umberto Balottin, Pierangelo Veggiotti

Research output: Contribution to journalArticle


Purpose: The aim of this study was to evaluate the long-term cognitive outcome in children with continuous spikes and waves during slow wave sleep (CSWSsyndrome). Methods: We reviewed the neuropsychological tests of 25 children diagnosed with CSWS between 1987 and 2010 and with a mean follow-up of 13.5 years. Key Findings: Cognitive performances worsened during CSWS in virtually all patients. Seven patients (28%) with nonlesional epilepsy had a positive outcome; three patients (12%) showed persistence of motor deficit without involvement of cognitive functions; and seven patients (28%) who presented a long duration of CSWS (mean = 28.1 months) had a negative cognitive outcome. In 6 patients (24%) with structural or metabolic disorders before CSWS onset cognitive outcomes did not change; 2 patients (8%) had a negative outcome irrespective of the duration or presence of other neurologic disorders before CSWS onset. Forty-four percent of children with CSWS demonstrated permanent cognitive impairment. Significance: The long-term outcome of CSWS syndrome is variable and seems to depend on treatment response, disease duration, and underlying etiology. Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
Issue numberSUPPL.7
Publication statusPublished - Oct 2013



  • CSWS
  • Epilepsy
  • ESES
  • Neuropsychological evaluation
  • Outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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