Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Zorana J Andersen, Marie Pedersen, Gudrun Weinmayr, Massimo Stafoggia, Claudia Galassi, Jeanette T Jørgensen, Johan N Sommar, Bertil Forsberg, David Olsson, Bente Oftedal, Gunn Marit Aasvang, Per Schwarze, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Claes-Göran Östenson, Laura Fratiglioni, Kirsten T Eriksen, Aslak H PoulsenAnne Tjønneland, Elvira Vaclavik Bräuner, Petra H Peeters, Bas Bueno-de-Mesquita, Andrea Jaensch, Gabriele Nagel, Alois Lang, Meng Wang, Ming-Yi Tsai, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Enrica Migliore, Roel Vermeulen, Ranjeet Sokhi, Menno Keuken, Kees de Hoogh, Rob Beelen, Paolo Vineis, Giulia Cesaroni, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen

Research output: Contribution to journalArticle

Abstract

Background: Epidemiological evidence on the association between ambient air pollution and brain tumor risk is sparse and inconsistent.

Methods: In 12 cohorts from 6 European countries, individual estimates of annual mean air pollution levels at the baseline residence were estimated by standardized land-use regression models developed within the ESCAPE and TRANSPHORM projects: particulate matter (PM) ≤2.5, ≤10, and 2.5-10 μm in diameter (PM2.5, PM10, and PMcoarse), PM2.5 absorbance, nitrogen oxides (NO2 and NOx) and elemental composition of PM. We estimated cohort-specific associations of air pollutant concentrations and traffic intensity with total, malignant, and nonmalignant brain tumor, in separate Cox regression models, adjusting for risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.

Results: Of 282194 subjects from 12 cohorts, 466 developed malignant brain tumors during 12 years of follow-up. Six of the cohorts also had data on nonmalignant brain tumor, where among 106786 subjects, 366 developed brain tumor: 176 nonmalignant and 190 malignant. We found a positive, statistically nonsignificant association between malignant brain tumor and PM2.5 absorbance (hazard ratio and 95% CI: 1.67; 0.89-3.14 per 10-5/m3), and weak positive or null associations with the other pollutants. Hazard ratio for PM2.5 absorbance (1.01; 0.38-2.71 per 10-5/m3) and all other pollutants were lower for nonmalignant than for malignant brain tumors.

Conclusion: We found suggestive evidence of an association between long-term exposure to PM2.5 absorbance indicating traffic-related air pollution and malignant brain tumors, and no association with overall or nonmalignant brain tumors.

Original languageEnglish
Pages (from-to)420-432
Number of pages13
JournalNeuro-Oncology
Volume20
Issue number3
DOIs
Publication statusPublished - Feb 19 2018

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Air Pollution
Brain Neoplasms
Cohort Studies
Incidence
Particulate Matter
Nitrogen Dioxide
Air Pollutants
Proportional Hazards Models
Meta-Analysis

Keywords

  • Adult
  • Air Pollution/adverse effects
  • Brain Neoplasms/epidemiology
  • Cohort Studies
  • Environmental Exposure/adverse effects
  • Europe/epidemiology
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Particulate Matter/adverse effects
  • Prognosis
  • Risk Factors

Cite this

Andersen, Z. J., Pedersen, M., Weinmayr, G., Stafoggia, M., Galassi, C., Jørgensen, J. T., ... Raaschou-Nielsen, O. (2018). Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE). Neuro-Oncology, 20(3), 420-432. https://doi.org/10.1093/neuonc/nox163

Long-term exposure to ambient air pollution and incidence of brain tumor : the European Study of Cohorts for Air Pollution Effects (ESCAPE). / Andersen, Zorana J; Pedersen, Marie; Weinmayr, Gudrun; Stafoggia, Massimo; Galassi, Claudia; Jørgensen, Jeanette T; Sommar, Johan N; Forsberg, Bertil; Olsson, David; Oftedal, Bente; Aasvang, Gunn Marit; Schwarze, Per; Pyko, Andrei; Pershagen, Göran; Korek, Michal; Faire, Ulf De; Östenson, Claes-Göran; Fratiglioni, Laura; Eriksen, Kirsten T; Poulsen, Aslak H; Tjønneland, Anne; Bräuner, Elvira Vaclavik; Peeters, Petra H; Bueno-de-Mesquita, Bas; Jaensch, Andrea; Nagel, Gabriele; Lang, Alois; Wang, Meng; Tsai, Ming-Yi; Grioni, Sara; Marcon, Alessandro; Krogh, Vittorio; Ricceri, Fulvio; Sacerdote, Carlotta; Migliore, Enrica; Vermeulen, Roel; Sokhi, Ranjeet; Keuken, Menno; de Hoogh, Kees; Beelen, Rob; Vineis, Paolo; Cesaroni, Giulia; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.

In: Neuro-Oncology, Vol. 20, No. 3, 19.02.2018, p. 420-432.

Research output: Contribution to journalArticle

Andersen, ZJ, Pedersen, M, Weinmayr, G, Stafoggia, M, Galassi, C, Jørgensen, JT, Sommar, JN, Forsberg, B, Olsson, D, Oftedal, B, Aasvang, GM, Schwarze, P, Pyko, A, Pershagen, G, Korek, M, Faire, UD, Östenson, C-G, Fratiglioni, L, Eriksen, KT, Poulsen, AH, Tjønneland, A, Bräuner, EV, Peeters, PH, Bueno-de-Mesquita, B, Jaensch, A, Nagel, G, Lang, A, Wang, M, Tsai, M-Y, Grioni, S, Marcon, A, Krogh, V, Ricceri, F, Sacerdote, C, Migliore, E, Vermeulen, R, Sokhi, R, Keuken, M, de Hoogh, K, Beelen, R, Vineis, P, Cesaroni, G, Brunekreef, B, Hoek, G & Raaschou-Nielsen, O 2018, 'Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE)', Neuro-Oncology, vol. 20, no. 3, pp. 420-432. https://doi.org/10.1093/neuonc/nox163
Andersen, Zorana J ; Pedersen, Marie ; Weinmayr, Gudrun ; Stafoggia, Massimo ; Galassi, Claudia ; Jørgensen, Jeanette T ; Sommar, Johan N ; Forsberg, Bertil ; Olsson, David ; Oftedal, Bente ; Aasvang, Gunn Marit ; Schwarze, Per ; Pyko, Andrei ; Pershagen, Göran ; Korek, Michal ; Faire, Ulf De ; Östenson, Claes-Göran ; Fratiglioni, Laura ; Eriksen, Kirsten T ; Poulsen, Aslak H ; Tjønneland, Anne ; Bräuner, Elvira Vaclavik ; Peeters, Petra H ; Bueno-de-Mesquita, Bas ; Jaensch, Andrea ; Nagel, Gabriele ; Lang, Alois ; Wang, Meng ; Tsai, Ming-Yi ; Grioni, Sara ; Marcon, Alessandro ; Krogh, Vittorio ; Ricceri, Fulvio ; Sacerdote, Carlotta ; Migliore, Enrica ; Vermeulen, Roel ; Sokhi, Ranjeet ; Keuken, Menno ; de Hoogh, Kees ; Beelen, Rob ; Vineis, Paolo ; Cesaroni, Giulia ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole. / Long-term exposure to ambient air pollution and incidence of brain tumor : the European Study of Cohorts for Air Pollution Effects (ESCAPE). In: Neuro-Oncology. 2018 ; Vol. 20, No. 3. pp. 420-432.
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abstract = "Background: Epidemiological evidence on the association between ambient air pollution and brain tumor risk is sparse and inconsistent.Methods: In 12 cohorts from 6 European countries, individual estimates of annual mean air pollution levels at the baseline residence were estimated by standardized land-use regression models developed within the ESCAPE and TRANSPHORM projects: particulate matter (PM) ≤2.5, ≤10, and 2.5-10 μm in diameter (PM2.5, PM10, and PMcoarse), PM2.5 absorbance, nitrogen oxides (NO2 and NOx) and elemental composition of PM. We estimated cohort-specific associations of air pollutant concentrations and traffic intensity with total, malignant, and nonmalignant brain tumor, in separate Cox regression models, adjusting for risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.Results: Of 282194 subjects from 12 cohorts, 466 developed malignant brain tumors during 12 years of follow-up. Six of the cohorts also had data on nonmalignant brain tumor, where among 106786 subjects, 366 developed brain tumor: 176 nonmalignant and 190 malignant. We found a positive, statistically nonsignificant association between malignant brain tumor and PM2.5 absorbance (hazard ratio and 95{\%} CI: 1.67; 0.89-3.14 per 10-5/m3), and weak positive or null associations with the other pollutants. Hazard ratio for PM2.5 absorbance (1.01; 0.38-2.71 per 10-5/m3) and all other pollutants were lower for nonmalignant than for malignant brain tumors.Conclusion: We found suggestive evidence of an association between long-term exposure to PM2.5 absorbance indicating traffic-related air pollution and malignant brain tumors, and no association with overall or nonmalignant brain tumors.",
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TY - JOUR

T1 - Long-term exposure to ambient air pollution and incidence of brain tumor

T2 - the European Study of Cohorts for Air Pollution Effects (ESCAPE)

AU - Andersen, Zorana J

AU - Pedersen, Marie

AU - Weinmayr, Gudrun

AU - Stafoggia, Massimo

AU - Galassi, Claudia

AU - Jørgensen, Jeanette T

AU - Sommar, Johan N

AU - Forsberg, Bertil

AU - Olsson, David

AU - Oftedal, Bente

AU - Aasvang, Gunn Marit

AU - Schwarze, Per

AU - Pyko, Andrei

AU - Pershagen, Göran

AU - Korek, Michal

AU - Faire, Ulf De

AU - Östenson, Claes-Göran

AU - Fratiglioni, Laura

AU - Eriksen, Kirsten T

AU - Poulsen, Aslak H

AU - Tjønneland, Anne

AU - Bräuner, Elvira Vaclavik

AU - Peeters, Petra H

AU - Bueno-de-Mesquita, Bas

AU - Jaensch, Andrea

AU - Nagel, Gabriele

AU - Lang, Alois

AU - Wang, Meng

AU - Tsai, Ming-Yi

AU - Grioni, Sara

AU - Marcon, Alessandro

AU - Krogh, Vittorio

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Migliore, Enrica

AU - Vermeulen, Roel

AU - Sokhi, Ranjeet

AU - Keuken, Menno

AU - de Hoogh, Kees

AU - Beelen, Rob

AU - Vineis, Paolo

AU - Cesaroni, Giulia

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

N1 - © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.

PY - 2018/2/19

Y1 - 2018/2/19

N2 - Background: Epidemiological evidence on the association between ambient air pollution and brain tumor risk is sparse and inconsistent.Methods: In 12 cohorts from 6 European countries, individual estimates of annual mean air pollution levels at the baseline residence were estimated by standardized land-use regression models developed within the ESCAPE and TRANSPHORM projects: particulate matter (PM) ≤2.5, ≤10, and 2.5-10 μm in diameter (PM2.5, PM10, and PMcoarse), PM2.5 absorbance, nitrogen oxides (NO2 and NOx) and elemental composition of PM. We estimated cohort-specific associations of air pollutant concentrations and traffic intensity with total, malignant, and nonmalignant brain tumor, in separate Cox regression models, adjusting for risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.Results: Of 282194 subjects from 12 cohorts, 466 developed malignant brain tumors during 12 years of follow-up. Six of the cohorts also had data on nonmalignant brain tumor, where among 106786 subjects, 366 developed brain tumor: 176 nonmalignant and 190 malignant. We found a positive, statistically nonsignificant association between malignant brain tumor and PM2.5 absorbance (hazard ratio and 95% CI: 1.67; 0.89-3.14 per 10-5/m3), and weak positive or null associations with the other pollutants. Hazard ratio for PM2.5 absorbance (1.01; 0.38-2.71 per 10-5/m3) and all other pollutants were lower for nonmalignant than for malignant brain tumors.Conclusion: We found suggestive evidence of an association between long-term exposure to PM2.5 absorbance indicating traffic-related air pollution and malignant brain tumors, and no association with overall or nonmalignant brain tumors.

AB - Background: Epidemiological evidence on the association between ambient air pollution and brain tumor risk is sparse and inconsistent.Methods: In 12 cohorts from 6 European countries, individual estimates of annual mean air pollution levels at the baseline residence were estimated by standardized land-use regression models developed within the ESCAPE and TRANSPHORM projects: particulate matter (PM) ≤2.5, ≤10, and 2.5-10 μm in diameter (PM2.5, PM10, and PMcoarse), PM2.5 absorbance, nitrogen oxides (NO2 and NOx) and elemental composition of PM. We estimated cohort-specific associations of air pollutant concentrations and traffic intensity with total, malignant, and nonmalignant brain tumor, in separate Cox regression models, adjusting for risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.Results: Of 282194 subjects from 12 cohorts, 466 developed malignant brain tumors during 12 years of follow-up. Six of the cohorts also had data on nonmalignant brain tumor, where among 106786 subjects, 366 developed brain tumor: 176 nonmalignant and 190 malignant. We found a positive, statistically nonsignificant association between malignant brain tumor and PM2.5 absorbance (hazard ratio and 95% CI: 1.67; 0.89-3.14 per 10-5/m3), and weak positive or null associations with the other pollutants. Hazard ratio for PM2.5 absorbance (1.01; 0.38-2.71 per 10-5/m3) and all other pollutants were lower for nonmalignant than for malignant brain tumors.Conclusion: We found suggestive evidence of an association between long-term exposure to PM2.5 absorbance indicating traffic-related air pollution and malignant brain tumors, and no association with overall or nonmalignant brain tumors.

KW - Adult

KW - Air Pollution/adverse effects

KW - Brain Neoplasms/epidemiology

KW - Cohort Studies

KW - Environmental Exposure/adverse effects

KW - Europe/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Particulate Matter/adverse effects

KW - Prognosis

KW - Risk Factors

U2 - 10.1093/neuonc/nox163

DO - 10.1093/neuonc/nox163

M3 - Article

C2 - 29016987

VL - 20

SP - 420

EP - 432

JO - Neuro-Oncology

JF - Neuro-Oncology

SN - 1522-8517

IS - 3

ER -