TY - JOUR
T1 - Long-term follow-up in children with benign convulsions associated with gastroenteritis
AU - Verrotti, Alberto
AU - Moavero, Romina
AU - Vigevano, Federico
AU - Cantonetti, Laura
AU - Guerra, Azzurra
AU - Spezia, Elisabetta
AU - Tricarico, Antonella
AU - Nanni, Giuliana
AU - Agostinelli, Sergio
AU - Chiarelli, Francesco
AU - Parisi, Pasquale
AU - Capovilla, Giuseppe
AU - Beccaria, Francesca
AU - Spalice, Alberto
AU - Coppola, Giangennaro
AU - Franzoni, Emilio
AU - Gentile, Valentina
AU - Casellato, Susanna
AU - Veggiotti, Pierangelo
AU - Malgesini, Sara
AU - Crichiutti, Giovanni
AU - Balestri, Paolo
AU - Grosso, Salvatore
AU - Zamponi, Nelia
AU - Incorpora, Gemma
AU - Savasta, Salvatore
AU - Costa, Paola
AU - Pruna, Dario
AU - Cusmai, Raffaella
PY - 2014
Y1 - 2014
N2 - Background The outcome of benign convulsions associated with gastroenteritis (CwG) has generally been reported as being excellent. However, these data need to be confirmed in studies with longer follow-up evaluations. Aim To assess the long-term neurological outcome of a large sample of children presenting with CwG. Methods We reviewed clinical features of 81 subjects presenting with CwG (1994-2010) from three different Italian centers with a follow-up period of at least 3 years. Results Follow-up period ranged from 39 months to 15 years (mean 9.8 years). Neurological examination and cognitive level at the last evaluation were normal in all the patients. A mild attention deficit was detected in three cases (3.7%). Fourteen children (17.3%) received chronic anti-epileptic therapy. Interictal EEG abnormalities detected at onset in 20 patients (24.7%) reverted to normal. Transient EEG epileptiform abnormalities were detected in other three cases (3.7%), and a transient photosensitivity in one (1.2%). No recurrence of CwG was observed. Three patients (3.7%) presented with a febrile seizure and two (2.5%) with an unprovoked seizure, but none developed epilepsy. Conclusions The long-term evaluation of children with CwG confirms the excellent prognosis of this condition, with normal psychomotor development and low risk of relapse and of subsequent epilepsy.
AB - Background The outcome of benign convulsions associated with gastroenteritis (CwG) has generally been reported as being excellent. However, these data need to be confirmed in studies with longer follow-up evaluations. Aim To assess the long-term neurological outcome of a large sample of children presenting with CwG. Methods We reviewed clinical features of 81 subjects presenting with CwG (1994-2010) from three different Italian centers with a follow-up period of at least 3 years. Results Follow-up period ranged from 39 months to 15 years (mean 9.8 years). Neurological examination and cognitive level at the last evaluation were normal in all the patients. A mild attention deficit was detected in three cases (3.7%). Fourteen children (17.3%) received chronic anti-epileptic therapy. Interictal EEG abnormalities detected at onset in 20 patients (24.7%) reverted to normal. Transient EEG epileptiform abnormalities were detected in other three cases (3.7%), and a transient photosensitivity in one (1.2%). No recurrence of CwG was observed. Three patients (3.7%) presented with a febrile seizure and two (2.5%) with an unprovoked seizure, but none developed epilepsy. Conclusions The long-term evaluation of children with CwG confirms the excellent prognosis of this condition, with normal psychomotor development and low risk of relapse and of subsequent epilepsy.
KW - Anti-epileptic drugs
KW - Gastroenteritis
KW - Long-term follow-up
KW - Seizure relapse
KW - Seizures
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U2 - 10.1016/j.ejpn.2014.04.006
DO - 10.1016/j.ejpn.2014.04.006
M3 - Article
C2 - 24780603
AN - SCOPUS:84906939186
VL - 18
SP - 572
EP - 577
JO - European Journal of Paediatric Neurology
JF - European Journal of Paediatric Neurology
SN - 1090-3798
IS - 5
ER -