Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes

R. Martino, A. Henseler, M. Van Lint, N. Schaap, J. Finke, D. Beelen, S. Vigouroux, E. P. Alessandrino, G. J. Mufti, J. H. Veelken, B. Bruno, I. Yakoub-Agha, L. Volin, J. Maertens, R. Or, V. Leblond, M. Rovira, P. Kalhs, A. F. Alvarez, A. Vitek & 5 others J. Sierra, E. Wagner, M. Robin, T. De Witte, N. Kröger

Research output: Contribution to journalArticle

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Abstract

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P <0.01). In addition, long-term follow-up confirms the importance of other variables on 13-year OS, mainly MDS risk category, disease phase, cytogenetics and receiving a high donor cell dose, irrespective of the conditioning regimen used.
Original languageEnglish
Pages (from-to)1107-1112
Number of pages6
JournalBone Marrow Transplantation
Volume52
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

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Myelodysplastic Syndromes
Homologous Transplantation
Tissue Donors
Conditioning (Psychology)
Survival
Cytogenetics
Multicenter Studies
Siblings
Multivariate Analysis
Retrospective Studies
Transplantation
Recurrence
Mortality

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Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes. / Martino, R.; Henseler, A.; Van Lint, M.; Schaap, N.; Finke, J.; Beelen, D.; Vigouroux, S.; Alessandrino, E. P.; Mufti, G. J.; Veelken, J. H.; Bruno, B.; Yakoub-Agha, I.; Volin, L.; Maertens, J.; Or, R.; Leblond, V.; Rovira, M.; Kalhs, P.; Alvarez, A. F.; Vitek, A.; Sierra, J.; Wagner, E.; Robin, M.; De Witte, T.; Kröger, N.

In: Bone Marrow Transplantation, Vol. 52, No. 8, 01.08.2017, p. 1107-1112.

Research output: Contribution to journalArticle

Martino, R, Henseler, A, Van Lint, M, Schaap, N, Finke, J, Beelen, D, Vigouroux, S, Alessandrino, EP, Mufti, GJ, Veelken, JH, Bruno, B, Yakoub-Agha, I, Volin, L, Maertens, J, Or, R, Leblond, V, Rovira, M, Kalhs, P, Alvarez, AF, Vitek, A, Sierra, J, Wagner, E, Robin, M, De Witte, T & Kröger, N 2017, 'Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes', Bone Marrow Transplantation, vol. 52, no. 8, pp. 1107-1112. https://doi.org/10.1038/bmt.2017.19
Martino, R. ; Henseler, A. ; Van Lint, M. ; Schaap, N. ; Finke, J. ; Beelen, D. ; Vigouroux, S. ; Alessandrino, E. P. ; Mufti, G. J. ; Veelken, J. H. ; Bruno, B. ; Yakoub-Agha, I. ; Volin, L. ; Maertens, J. ; Or, R. ; Leblond, V. ; Rovira, M. ; Kalhs, P. ; Alvarez, A. F. ; Vitek, A. ; Sierra, J. ; Wagner, E. ; Robin, M. ; De Witte, T. ; Kröger, N. / Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes. In: Bone Marrow Transplantation. 2017 ; Vol. 52, No. 8. pp. 1107-1112.
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AU - Henseler, A.

AU - Van Lint, M.

AU - Schaap, N.

AU - Finke, J.

AU - Beelen, D.

AU - Vigouroux, S.

AU - Alessandrino, E. P.

AU - Mufti, G. J.

AU - Veelken, J. H.

AU - Bruno, B.

AU - Yakoub-Agha, I.

AU - Volin, L.

AU - Maertens, J.

AU - Or, R.

AU - Leblond, V.

AU - Rovira, M.

AU - Kalhs, P.

AU - Alvarez, A. F.

AU - Vitek, A.

AU - Sierra, J.

AU - Wagner, E.

AU - Robin, M.

AU - De Witte, T.

AU - Kröger, N.

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Y1 - 2017/8/1

N2 - © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P <0.01). In addition, long-term follow-up confirms the importance of other variables on 13-year OS, mainly MDS risk category, disease phase, cytogenetics and receiving a high donor cell dose, irrespective of the conditioning regimen used.

AB - © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P <0.01). In addition, long-term follow-up confirms the importance of other variables on 13-year OS, mainly MDS risk category, disease phase, cytogenetics and receiving a high donor cell dose, irrespective of the conditioning regimen used.

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