Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes

R. Martino, A. Henseler, M. van Lint, N. Schaap, J. Finke, D. Beelen, S. Vigouroux, E. P. Alessandrino, G. J. Mufti, J. H. Veelken, B. Bruno, I. Yakoub-Agha, L. Volin, J. Maertens, R. Or, V. Leblond, M. Rovira, P. Kalhs, A. F. Alvarez, A. VitekJ. Sierra, E. Wagner, M. Robin, T. de Witte, N. Kroger

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Abstract

This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P
Original languageEnglish
Pages (from-to)1107-1112
Number of pages6
JournalBone Marrow Transplantation
Volume52
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

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    Martino, R., Henseler, A., Lint, M. V., Schaap, N., Finke, J., Beelen, D., Vigouroux, S., Alessandrino, E. P., Mufti, G. J., Veelken, J. H., Bruno, B., Yakoub-Agha, I., Volin, L., Maertens, J., Or, R., Leblond, V., Rovira, M., Kalhs, P., Alvarez, A. F., ... Kroger, N. (2017). Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes. Bone Marrow Transplantation, 52(8), 1107-1112. https://doi.org/10.1038/bmt.2017.19 [doi]