Long-term follow-up of achalasia patients treated with botulinum toxin

V. D'Onofrio, P. Miletto, G. Leandro, G. Iaquinto

Research output: Contribution to journalArticlepeer-review


Aims. To evaluate long-term efficacy of intrasphincteric injection of botulinum toxin in untreated achalasia patients; to analyse whether age can be a predictor of response; and to verify whether any objective measurements correlate with symptom relief. Materials and Methods. A total of 37 patients (mean age 61.4±17.5 years) were enrolled, all of whom injected endoscopically with 100 U of botulinum toxin. Symptom score, oesophageal manometry and oesophageal radionuclide emptying were assessed prior to treatment and 4 weeks, 3 months and 1 year after botulinum toxin. In the case of failure or relapse (symptom score >2), treatment was repeated. Results. All but 6 patients (83.7%) were in clinical remission one month after botulinum toxin. At 12 months, mean symptom score was 0.9±0.5 (p

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalDigestive and Liver Disease
Issue number2
Publication statusPublished - 2002


  • Achalasia
  • Botulinum toxin

ASJC Scopus subject areas

  • Gastroenterology

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