Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy

Maria Gabriella Mazzucconi, Maria Cristina Arista, Monica Peraino, Antonio Chistolini, Carla Felici, Vittorio Francavilla, Elvira Macale, Laura Conti, Giuseppe Maria Gandolfo

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We studied the general outcome in 94 adult patients with autoimmune thrombocytopenic purpura (ATP) submitted to splenectomy. Of 84/94 patients who presented a complete or partial response 30 d after splenectomy, 16 (19%) showed one or more relapses. The clinical situation of the 81 patients still under observation is as follows: 13 unrensponsive, 60 completely or partially responsive, without relapses during the follow-up, 8 completely or partially responsive after one or more relapses. No correlation was found between the favourable splenectomy outcome and age at splenectomy, the diagnosis- splenectomy interval and initial response to corticosteroids. The probability of disease-free survival is 83%, projected at 10 yr, while the overall survival is 93%, projected at 10 yr. PAIgG levels of the normal subjects and of responding patients were found to be similar, while in the groups of non- responding/relapsing patients, significantly higher values of PAIgG were detected, as compared to the control group.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalEuropean Journal of Haematology
Volume62
Issue number4
Publication statusPublished - 1999

Fingerprint

Idiopathic Thrombocytopenic Purpura
Splenectomy
Recurrence
Disease-Free Survival
Adrenal Cortex Hormones
Observation
Control Groups
Survival

Keywords

  • Autoimmune thrombocytopenic purpura
  • Splenectomy

ASJC Scopus subject areas

  • Hematology

Cite this

Mazzucconi, M. G., Arista, M. C., Peraino, M., Chistolini, A., Felici, C., Francavilla, V., ... Gandolfo, G. M. (1999). Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy. European Journal of Haematology, 62(4), 219-222.

Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy. / Mazzucconi, Maria Gabriella; Arista, Maria Cristina; Peraino, Monica; Chistolini, Antonio; Felici, Carla; Francavilla, Vittorio; Macale, Elvira; Conti, Laura; Gandolfo, Giuseppe Maria.

In: European Journal of Haematology, Vol. 62, No. 4, 1999, p. 219-222.

Research output: Contribution to journalArticle

Mazzucconi, MG, Arista, MC, Peraino, M, Chistolini, A, Felici, C, Francavilla, V, Macale, E, Conti, L & Gandolfo, GM 1999, 'Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy', European Journal of Haematology, vol. 62, no. 4, pp. 219-222.
Mazzucconi MG, Arista MC, Peraino M, Chistolini A, Felici C, Francavilla V et al. Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy. European Journal of Haematology. 1999;62(4):219-222.
Mazzucconi, Maria Gabriella ; Arista, Maria Cristina ; Peraino, Monica ; Chistolini, Antonio ; Felici, Carla ; Francavilla, Vittorio ; Macale, Elvira ; Conti, Laura ; Gandolfo, Giuseppe Maria. / Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy. In: European Journal of Haematology. 1999 ; Vol. 62, No. 4. pp. 219-222.
@article{b861ecffc03f44928568805e03c5998a,
title = "Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy",
abstract = "We studied the general outcome in 94 adult patients with autoimmune thrombocytopenic purpura (ATP) submitted to splenectomy. Of 84/94 patients who presented a complete or partial response 30 d after splenectomy, 16 (19{\%}) showed one or more relapses. The clinical situation of the 81 patients still under observation is as follows: 13 unrensponsive, 60 completely or partially responsive, without relapses during the follow-up, 8 completely or partially responsive after one or more relapses. No correlation was found between the favourable splenectomy outcome and age at splenectomy, the diagnosis- splenectomy interval and initial response to corticosteroids. The probability of disease-free survival is 83{\%}, projected at 10 yr, while the overall survival is 93{\%}, projected at 10 yr. PAIgG levels of the normal subjects and of responding patients were found to be similar, while in the groups of non- responding/relapsing patients, significantly higher values of PAIgG were detected, as compared to the control group.",
keywords = "Autoimmune thrombocytopenic purpura, Splenectomy",
author = "Mazzucconi, {Maria Gabriella} and Arista, {Maria Cristina} and Monica Peraino and Antonio Chistolini and Carla Felici and Vittorio Francavilla and Elvira Macale and Laura Conti and Gandolfo, {Giuseppe Maria}",
year = "1999",
language = "English",
volume = "62",
pages = "219--222",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "4",

}

TY - JOUR

T1 - Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy

AU - Mazzucconi, Maria Gabriella

AU - Arista, Maria Cristina

AU - Peraino, Monica

AU - Chistolini, Antonio

AU - Felici, Carla

AU - Francavilla, Vittorio

AU - Macale, Elvira

AU - Conti, Laura

AU - Gandolfo, Giuseppe Maria

PY - 1999

Y1 - 1999

N2 - We studied the general outcome in 94 adult patients with autoimmune thrombocytopenic purpura (ATP) submitted to splenectomy. Of 84/94 patients who presented a complete or partial response 30 d after splenectomy, 16 (19%) showed one or more relapses. The clinical situation of the 81 patients still under observation is as follows: 13 unrensponsive, 60 completely or partially responsive, without relapses during the follow-up, 8 completely or partially responsive after one or more relapses. No correlation was found between the favourable splenectomy outcome and age at splenectomy, the diagnosis- splenectomy interval and initial response to corticosteroids. The probability of disease-free survival is 83%, projected at 10 yr, while the overall survival is 93%, projected at 10 yr. PAIgG levels of the normal subjects and of responding patients were found to be similar, while in the groups of non- responding/relapsing patients, significantly higher values of PAIgG were detected, as compared to the control group.

AB - We studied the general outcome in 94 adult patients with autoimmune thrombocytopenic purpura (ATP) submitted to splenectomy. Of 84/94 patients who presented a complete or partial response 30 d after splenectomy, 16 (19%) showed one or more relapses. The clinical situation of the 81 patients still under observation is as follows: 13 unrensponsive, 60 completely or partially responsive, without relapses during the follow-up, 8 completely or partially responsive after one or more relapses. No correlation was found between the favourable splenectomy outcome and age at splenectomy, the diagnosis- splenectomy interval and initial response to corticosteroids. The probability of disease-free survival is 83%, projected at 10 yr, while the overall survival is 93%, projected at 10 yr. PAIgG levels of the normal subjects and of responding patients were found to be similar, while in the groups of non- responding/relapsing patients, significantly higher values of PAIgG were detected, as compared to the control group.

KW - Autoimmune thrombocytopenic purpura

KW - Splenectomy

UR - http://www.scopus.com/inward/record.url?scp=0032913788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032913788&partnerID=8YFLogxK

M3 - Article

VL - 62

SP - 219

EP - 222

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 4

ER -