Abstract
We studied the general outcome in 94 adult patients with autoimmune thrombocytopenic purpura (ATP) submitted to splenectomy. Of 84/94 patients who presented a complete or partial response 30 d after splenectomy, 16 (19%) showed one or more relapses. The clinical situation of the 81 patients still under observation is as follows: 13 unrensponsive, 60 completely or partially responsive, without relapses during the follow-up, 8 completely or partially responsive after one or more relapses. No correlation was found between the favourable splenectomy outcome and age at splenectomy, the diagnosis- splenectomy interval and initial response to corticosteroids. The probability of disease-free survival is 83%, projected at 10 yr, while the overall survival is 93%, projected at 10 yr. PAIgG levels of the normal subjects and of responding patients were found to be similar, while in the groups of non- responding/relapsing patients, significantly higher values of PAIgG were detected, as compared to the control group.
| Original language | English |
|---|---|
| Pages (from-to) | 219-222 |
| Number of pages | 4 |
| Journal | European Journal of Haematology |
| Volume | 62 |
| Issue number | 4 |
| Publication status | Published - 1999 |
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Keywords
- Autoimmune thrombocytopenic purpura
- Splenectomy
ASJC Scopus subject areas
- Hematology
Cite this
Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy. / Mazzucconi, Maria Gabriella; Arista, Maria Cristina; Peraino, Monica; Chistolini, Antonio; Felici, Carla; Francavilla, Vittorio; Macale, Elvira; Conti, Laura; Gandolfo, Giuseppe Maria.
In: European Journal of Haematology, Vol. 62, No. 4, 1999, p. 219-222.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy
AU - Mazzucconi, Maria Gabriella
AU - Arista, Maria Cristina
AU - Peraino, Monica
AU - Chistolini, Antonio
AU - Felici, Carla
AU - Francavilla, Vittorio
AU - Macale, Elvira
AU - Conti, Laura
AU - Gandolfo, Giuseppe Maria
PY - 1999
Y1 - 1999
N2 - We studied the general outcome in 94 adult patients with autoimmune thrombocytopenic purpura (ATP) submitted to splenectomy. Of 84/94 patients who presented a complete or partial response 30 d after splenectomy, 16 (19%) showed one or more relapses. The clinical situation of the 81 patients still under observation is as follows: 13 unrensponsive, 60 completely or partially responsive, without relapses during the follow-up, 8 completely or partially responsive after one or more relapses. No correlation was found between the favourable splenectomy outcome and age at splenectomy, the diagnosis- splenectomy interval and initial response to corticosteroids. The probability of disease-free survival is 83%, projected at 10 yr, while the overall survival is 93%, projected at 10 yr. PAIgG levels of the normal subjects and of responding patients were found to be similar, while in the groups of non- responding/relapsing patients, significantly higher values of PAIgG were detected, as compared to the control group.
AB - We studied the general outcome in 94 adult patients with autoimmune thrombocytopenic purpura (ATP) submitted to splenectomy. Of 84/94 patients who presented a complete or partial response 30 d after splenectomy, 16 (19%) showed one or more relapses. The clinical situation of the 81 patients still under observation is as follows: 13 unrensponsive, 60 completely or partially responsive, without relapses during the follow-up, 8 completely or partially responsive after one or more relapses. No correlation was found between the favourable splenectomy outcome and age at splenectomy, the diagnosis- splenectomy interval and initial response to corticosteroids. The probability of disease-free survival is 83%, projected at 10 yr, while the overall survival is 93%, projected at 10 yr. PAIgG levels of the normal subjects and of responding patients were found to be similar, while in the groups of non- responding/relapsing patients, significantly higher values of PAIgG were detected, as compared to the control group.
KW - Autoimmune thrombocytopenic purpura
KW - Splenectomy
UR - http://www.scopus.com/inward/record.url?scp=0032913788&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032913788&partnerID=8YFLogxK
M3 - Article
VL - 62
SP - 219
EP - 222
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 4
ER -