Long-term follow-up of cellular proliferation as a predictive index for the relapse of nasal polyposis

Ernesto Bruno, Ehab I. Mohamed, Mohamed Alessandrini, Sabino Russo, Stefania Schiaroli, Antonino De Lorenzo, Alberto Di Girolamo

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Abstract

Background: The objective of this study was to identify a reproducible clinical parameter for predicting relapses of nasal polyposis after surgery. Methods: Ninety-three patients who had undergone ethmoidectomy of bilateral nasal polyps were followed for 3 years. Nasal polyps were obtained from all patients, and cellular suspensions were analyzed individually using flow cytometry. Based on the percentage of cells in the S phase, we identified three groups of patients (high, medium, and low percentages). Results: A relapse of nasal polyposis was observed in 15.00, 70.00, and 100.00% of patients from the low-, medium-, and high-percentage groups, respectively. Patients suffering relapses had a high percentage of cells in the S phase. Conclusions: We identified two cutoff values for the percentage of cells in the S phase; above the first cutoff, some of the patients suffered relapses; above the second cut-off, all patients suffered relapses.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalAmerican Journal of Rhinology
Volume16
Issue number5
Publication statusPublished - Sep 2002

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Bruno, E., Mohamed, E. I., Alessandrini, M., Russo, S., Schiaroli, S., De Lorenzo, A., & Di Girolamo, A. (2002). Long-term follow-up of cellular proliferation as a predictive index for the relapse of nasal polyposis. American Journal of Rhinology, 16(5), 237-241.