Long-term follow-up of hepatitis C virus (HCV) infection in liver transplant patients

E. Villa, A. Grottola, P. Buttafoco, A. Merighi, I. Ferretti, P. Trande, P. Zoboli, L. Camellini, F. Callea, M. De Palma, C. Vecchi, R. Troisi, M. Camisasca, S. Rossi, G. Tordato, B. De Hemptinne, M. Podda, F. Manenti

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic hepatitis represents a frequent event after orthotopic liver transplantation (OLT). To ascertain the influence of HCV infection on the clinical and histological outcome of these patients, we have investigated the long-term outcome of 22 patients with end-stage chronic liver disease undergoing liver transplant focusing the attention on the role of different HCV genotypes in determining recurrence and severity of post-OLT liver disease. For all patients blood samples taken before OLT and 3 months, 1, 2 and 3 years after OLT were tested for antiHCV antibodies by two different enzyme-linked immune-assays and by recombinant immunoblot II and for the presence and type of HCV RNA by nested PCR (5' untranslated region and core gene primers). Of the 16 pre-OLT antiHCV-positive patients, 14 (87.5%) had recurrence of HCV infection while 2 cleared HCV. Pre-OLT genotype recurred in 11 of these 14 patients (2 genotype I, 8 genotype II - in 1 case associated with genotype III - and 1 genotype IV). Of the 6 pre-OLT antiHCV-negative patients, only 1 (16.6%) became persistently HCV-infected, with genotypes I and II. The recurrence of genotype II strictly related with development of severe chronic hepatitis while genotype I and IV were associated with milder forms of liver disease and were more easily cleared.

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalClinical Transplantation
Volume9
Issue number3 I
Publication statusPublished - 1995

Keywords

  • Genotypes
  • Hepatitis C virus
  • Liver transplant

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Fingerprint Dive into the research topics of 'Long-term follow-up of hepatitis C virus (HCV) infection in liver transplant patients'. Together they form a unique fingerprint.

Cite this