Long-term follow-up of multivessel percutaneous coronary intervention with drug-eluting stents for de novo lesions with correlation to the SYNTAX score

Robert T. Gerber, Alfonso Ielasi, Rasha Al-Lamee, Azeem Latib, Flavio Airoldi, Massimo Ferraro, Luca Ferri, Giorgio Bassanelli, Cosmo Godino, Andrew S P Sharp, Alaide Chieffo, Mauro Carlino, Matteo Montorfano, Giuseppe M. Sangiorgi, Antonio Colombo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Stent thrombosis (ST) and restenosis are concerns after percutaneous coronary intervention (PCI). Limited information exists concerning clinical and angiographic outcomes following multiple stent insertion. We therefore present the long-term outcome from drug-eluting stent (DES) insertion and correlate this with the Syntax score. Methods and Results: Between April 2002 and 2006, all patients that underwent multilesion PCI (defined as ≥4 DES) were included for analysis, and follow-up commenced from the point where the fourth stent was inserted. Three hundred and seventy-four patients were identified, comprising 1972 lesions; 99% had clinical (30±16 months), and 72% had angiographic follow-up. The mean number of stents implanted was 5.7±1.9 and with length of 137±50 mm and Syntax Score of 24±8. The Syntax score (SS) did not predict major adverse cardiac events (MACE) at long-term follow-up, which occurred in 33% in the low SS (33); P=ns. However, the number of stents implanted correlated with events [MACE: 12% (4 DES), 35% (4-6 DES), 61% (>6 DES)]. There were 11 (2.9%) definite and probable ST: four acute and subacute, three late, and four very late. Conclusions: This study demonstrates an acceptable occurrence of myocardial infarction, death, repeat revascularisation, and ST in patients with multivessel de novo lesions, which had better correlation with the number of DES inserted than the Syntax score.

Original languageEnglish
Pages (from-to)220-227
Number of pages8
JournalCardiovascular Revascularization Medicine
Volume12
Issue number4
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Drug-Eluting Stents
Percutaneous Coronary Intervention
Stents
Thrombosis
Myocardial Infarction

Keywords

  • Drug eluting stents
  • Restenosis
  • Revascularisation
  • Stent thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Long-term follow-up of multivessel percutaneous coronary intervention with drug-eluting stents for de novo lesions with correlation to the SYNTAX score. / Gerber, Robert T.; Ielasi, Alfonso; Al-Lamee, Rasha; Latib, Azeem; Airoldi, Flavio; Ferraro, Massimo; Ferri, Luca; Bassanelli, Giorgio; Godino, Cosmo; Sharp, Andrew S P; Chieffo, Alaide; Carlino, Mauro; Montorfano, Matteo; Sangiorgi, Giuseppe M.; Colombo, Antonio.

In: Cardiovascular Revascularization Medicine, Vol. 12, No. 4, 07.2011, p. 220-227.

Research output: Contribution to journalArticle

Gerber, Robert T. ; Ielasi, Alfonso ; Al-Lamee, Rasha ; Latib, Azeem ; Airoldi, Flavio ; Ferraro, Massimo ; Ferri, Luca ; Bassanelli, Giorgio ; Godino, Cosmo ; Sharp, Andrew S P ; Chieffo, Alaide ; Carlino, Mauro ; Montorfano, Matteo ; Sangiorgi, Giuseppe M. ; Colombo, Antonio. / Long-term follow-up of multivessel percutaneous coronary intervention with drug-eluting stents for de novo lesions with correlation to the SYNTAX score. In: Cardiovascular Revascularization Medicine. 2011 ; Vol. 12, No. 4. pp. 220-227.
@article{81ed65a37855423393ec79c1fd732df7,
title = "Long-term follow-up of multivessel percutaneous coronary intervention with drug-eluting stents for de novo lesions with correlation to the SYNTAX score",
abstract = "Background: Stent thrombosis (ST) and restenosis are concerns after percutaneous coronary intervention (PCI). Limited information exists concerning clinical and angiographic outcomes following multiple stent insertion. We therefore present the long-term outcome from drug-eluting stent (DES) insertion and correlate this with the Syntax score. Methods and Results: Between April 2002 and 2006, all patients that underwent multilesion PCI (defined as ≥4 DES) were included for analysis, and follow-up commenced from the point where the fourth stent was inserted. Three hundred and seventy-four patients were identified, comprising 1972 lesions; 99{\%} had clinical (30±16 months), and 72{\%} had angiographic follow-up. The mean number of stents implanted was 5.7±1.9 and with length of 137±50 mm and Syntax Score of 24±8. The Syntax score (SS) did not predict major adverse cardiac events (MACE) at long-term follow-up, which occurred in 33{\%} in the low SS (33); P=ns. However, the number of stents implanted correlated with events [MACE: 12{\%} (4 DES), 35{\%} (4-6 DES), 61{\%} (>6 DES)]. There were 11 (2.9{\%}) definite and probable ST: four acute and subacute, three late, and four very late. Conclusions: This study demonstrates an acceptable occurrence of myocardial infarction, death, repeat revascularisation, and ST in patients with multivessel de novo lesions, which had better correlation with the number of DES inserted than the Syntax score.",
keywords = "Drug eluting stents, Restenosis, Revascularisation, Stent thrombosis",
author = "Gerber, {Robert T.} and Alfonso Ielasi and Rasha Al-Lamee and Azeem Latib and Flavio Airoldi and Massimo Ferraro and Luca Ferri and Giorgio Bassanelli and Cosmo Godino and Sharp, {Andrew S P} and Alaide Chieffo and Mauro Carlino and Matteo Montorfano and Sangiorgi, {Giuseppe M.} and Antonio Colombo",
year = "2011",
month = "7",
doi = "10.1016/j.carrev.2010.10.002",
language = "English",
volume = "12",
pages = "220--227",
journal = "Cardiovascular Revascularization Medicine",
issn = "1553-8389",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Long-term follow-up of multivessel percutaneous coronary intervention with drug-eluting stents for de novo lesions with correlation to the SYNTAX score

AU - Gerber, Robert T.

AU - Ielasi, Alfonso

AU - Al-Lamee, Rasha

AU - Latib, Azeem

AU - Airoldi, Flavio

AU - Ferraro, Massimo

AU - Ferri, Luca

AU - Bassanelli, Giorgio

AU - Godino, Cosmo

AU - Sharp, Andrew S P

AU - Chieffo, Alaide

AU - Carlino, Mauro

AU - Montorfano, Matteo

AU - Sangiorgi, Giuseppe M.

AU - Colombo, Antonio

PY - 2011/7

Y1 - 2011/7

N2 - Background: Stent thrombosis (ST) and restenosis are concerns after percutaneous coronary intervention (PCI). Limited information exists concerning clinical and angiographic outcomes following multiple stent insertion. We therefore present the long-term outcome from drug-eluting stent (DES) insertion and correlate this with the Syntax score. Methods and Results: Between April 2002 and 2006, all patients that underwent multilesion PCI (defined as ≥4 DES) were included for analysis, and follow-up commenced from the point where the fourth stent was inserted. Three hundred and seventy-four patients were identified, comprising 1972 lesions; 99% had clinical (30±16 months), and 72% had angiographic follow-up. The mean number of stents implanted was 5.7±1.9 and with length of 137±50 mm and Syntax Score of 24±8. The Syntax score (SS) did not predict major adverse cardiac events (MACE) at long-term follow-up, which occurred in 33% in the low SS (33); P=ns. However, the number of stents implanted correlated with events [MACE: 12% (4 DES), 35% (4-6 DES), 61% (>6 DES)]. There were 11 (2.9%) definite and probable ST: four acute and subacute, three late, and four very late. Conclusions: This study demonstrates an acceptable occurrence of myocardial infarction, death, repeat revascularisation, and ST in patients with multivessel de novo lesions, which had better correlation with the number of DES inserted than the Syntax score.

AB - Background: Stent thrombosis (ST) and restenosis are concerns after percutaneous coronary intervention (PCI). Limited information exists concerning clinical and angiographic outcomes following multiple stent insertion. We therefore present the long-term outcome from drug-eluting stent (DES) insertion and correlate this with the Syntax score. Methods and Results: Between April 2002 and 2006, all patients that underwent multilesion PCI (defined as ≥4 DES) were included for analysis, and follow-up commenced from the point where the fourth stent was inserted. Three hundred and seventy-four patients were identified, comprising 1972 lesions; 99% had clinical (30±16 months), and 72% had angiographic follow-up. The mean number of stents implanted was 5.7±1.9 and with length of 137±50 mm and Syntax Score of 24±8. The Syntax score (SS) did not predict major adverse cardiac events (MACE) at long-term follow-up, which occurred in 33% in the low SS (33); P=ns. However, the number of stents implanted correlated with events [MACE: 12% (4 DES), 35% (4-6 DES), 61% (>6 DES)]. There were 11 (2.9%) definite and probable ST: four acute and subacute, three late, and four very late. Conclusions: This study demonstrates an acceptable occurrence of myocardial infarction, death, repeat revascularisation, and ST in patients with multivessel de novo lesions, which had better correlation with the number of DES inserted than the Syntax score.

KW - Drug eluting stents

KW - Restenosis

KW - Revascularisation

KW - Stent thrombosis

UR - http://www.scopus.com/inward/record.url?scp=79960723061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960723061&partnerID=8YFLogxK

U2 - 10.1016/j.carrev.2010.10.002

DO - 10.1016/j.carrev.2010.10.002

M3 - Article

VL - 12

SP - 220

EP - 227

JO - Cardiovascular Revascularization Medicine

JF - Cardiovascular Revascularization Medicine

SN - 1553-8389

IS - 4

ER -