Twenty-two drug-resistant epileptic pts (21 with complex partial seizures and 1 with Ramsay Hunt syndrome) who had been significantly improved by Vigabatrin during 2 previous controlled trials entered a long-term study with vigabatrin. Five pts were dropped from the study, although 2 of them had a significant seizure frequency decrease. The 17 pts still on Vigabatrin have been followed for a mean period of 20 months (range: 9-33); of them, 13 pts (76%) continue to have a 50% or more decrease in seizure frequency. The remaining 4 pts (24%) feel drug-helped because of a reduction of seizure frequency and intensity. Tolerance to Vigabatrin was good, with the most frequently reported unwanted effect being weight increase. Plasma concentrations of PHT were significantly reduced during long-term treatment. These results demonstrate that the good results obtained with Vigabatrin during the placebo-controlled trials are maintained during the long-term treatment.
|Title of host publication||Bollettino - Lega Italiana contro l'Epilessia|
|Number of pages||2|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Clinical Neurology