TY - JOUR
T1 - Long-term follow-up of pediatric MS patients starting treatment with injectable first-line agents: A multicentre, Italian, retrospective, observational study
T2 - Multiple sclerosis (Houndmills, Basingstoke, England)
AU - Baroncini, D
AU - Zaffaroni, M
AU - Moiola, L
AU - Lorefice, L
AU - Fenu, G
AU - Iaffaldano, P
AU - Simone, M
AU - Fanelli, F
AU - Patti, F
AU - D'Amico, E
AU - Capobianco, M
AU - Bertolotto, A
AU - Gallo, P
AU - Margoni, M
AU - Miante, S
AU - Milani, N
AU - Amato, MP
AU - Righini, I
AU - Bellantonio, P
AU - Scandellari, C
AU - Costantino, G
AU - Scarpini, E
AU - Bergamaschi, R
AU - Mallucci, G
AU - Comi, G
AU - Ghezzi, A
AU - Registry, on behalf of the iMED
AU - Neurologia, Gruppo di Studio SM-Società Italiana di
PY - 2019
Y1 - 2019
N2 - BACKGROUND: Few data are available on very long-term follow-up of pediatric multiple sclerosis (MS) patients treated with disease modifying treatments (DMTs). OBJECTIVES: To present a long-term follow-up of a cohort of Pediatric-MS patients starting injectable first-line agents. METHODS: Data regarding treatments, annualized relapse rate (ARR), Expanded Disability Status Scale (EDSS) score, and serious adverse event were collected. Baseline characteristics were tested in multivariate analysis to identify predictors of disease evolution. RESULTS: In total, 97 patients were followed for 12.5 ± 3.3 years. They started therapy at 13.9 ± 2.1 years, 88 with interferons and 9 with copaxone. During the whole follow-up, 82 patients changed therapy, switching to immunosuppressors/second-line treatment in 58% of cases. Compared to pre-treatment phase, the ARR was significantly reduced during the first treatment (from 3.2 ± 2.6 to 0.7 ± 1.5, p
AB - BACKGROUND: Few data are available on very long-term follow-up of pediatric multiple sclerosis (MS) patients treated with disease modifying treatments (DMTs). OBJECTIVES: To present a long-term follow-up of a cohort of Pediatric-MS patients starting injectable first-line agents. METHODS: Data regarding treatments, annualized relapse rate (ARR), Expanded Disability Status Scale (EDSS) score, and serious adverse event were collected. Baseline characteristics were tested in multivariate analysis to identify predictors of disease evolution. RESULTS: In total, 97 patients were followed for 12.5 ± 3.3 years. They started therapy at 13.9 ± 2.1 years, 88 with interferons and 9 with copaxone. During the whole follow-up, 82 patients changed therapy, switching to immunosuppressors/second-line treatment in 58% of cases. Compared to pre-treatment phase, the ARR was significantly reduced during the first treatment (from 3.2 ± 2.6 to 0.7 ± 1.5, p
U2 - 10.1177/1352458518754364
DO - 10.1177/1352458518754364
M3 - Article
VL - 25
SP - 399
EP - 407
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
IS - 3
ER -