Long-term follow-up study of genome damage elimination in patients with testicular seminoma exposed to ionising radiation during radiotherapy

Marija Gamulin, Jelena Katić, Mirta Milić, Mislav Grgić, Aleksandra Fučić

Research output: Contribution to journalArticlepeer-review

Abstract

The rate of genome damage elimination after therapeutic exposure to ionising radiation was estimated in stage I testicular seminoma patients monitored over a seven-year follow-up. DNA damage elimination in peripheral lymphocytes of ten subjects was analysed by the chromosome aberration assay. Seven years after the end of radiotherapy, significantly increased frequency of ring and dicentric chromosomes was still detected in comparison with baseline values. These results indicate the induction of genome instability. Long-term follow-up studies of cancer patients after radiotherapy could give us valuable information on the rate of genome damage elimination after exposure to ionising radiation and about the duration and manifestation of genome instability. This may be used in health risk assessment related to the possible development of secondary neoplasia. Studies such as this could have a great value both for oncology and radiation protection management protocols, especially after accidental overexposures.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalArhiv za Higijenu Rada i Toksikologiju
Volume62
Issue number1
DOIs
Publication statusPublished - Mar 1 2011

Keywords

  • chromosome aberration assay
  • dicentric chromosome
  • follow-up
  • genome instability
  • ionising radiation
  • secondary cancer

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology

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