Long-term follow-up study on the role of serum CA-125 as a prognostic factor in 221 newly diagnosed patients with Hodgkin's lymphoma

Filippo Russo, Secondo Lastoria, Gino Svanera, Gaetana Capobianco, Anna De Chiara, Raffaele Di Francia, Elisabetta Squame, Franco De Martinis, Antonio Pinto

Research output: Contribution to journalArticlepeer-review

Abstract

The present study has explored the possible value of sCA-125 as a prognostic factor in Hodgkin's lymphoma (HL). From August 1992 to June 2005 sCA-125 was measured at presentation and at the end of the treatments in 221 newly diagnosed adult patients with HL. In this study 90/221 (41%) patients showed a value greater than the standard upper limit of 35 U/ml, and 79/90 (88%) with an abnormal sCA-125 were at an advanced stage of the disease. Patients with elevated sCA-125 showed a significant reduction in complete remission (CR) rate (76%vs. 98%; p > 0.0001). Failure of normalization of sCA-125 during the treatment revealed that CR had not been reached. Furthermore, no traces of the glycoprotein sCA-125 were found in a series of paraffin-embedded samples coming from 15 patients of this study. In addition, soluble CA-125 was not detected in supernatants coming from four different Hodgkin-derived cell lines. The long-term follow-up revealed that the group of patients with sCA-125 lower than 35 U/ml, at diagnosis, had an estimated 92% event free survival (EFS) rate and a 94% overall survival (OS) rate, while the group of patients with sCA-125 greater than 35 U/ml had only a 60% EFS rate (log-rank 33.43, p > 0.0001) and a 70% OS rate (log-rank 23.52, p > 0.0001). Extranodal disease, severe lymphocytopenia and age proved to be the only standard factors that could represent a poor chance to survive. At multivariate analysis, high sCA-125, E sites

Original languageEnglish
Pages (from-to)723-730
Number of pages8
JournalLeukemia and Lymphoma
Volume48
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Hodgkin's lymphoma
  • Long-term follow-up
  • Prognosis
  • SCA-125

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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