Long-term haemopoiesis in human fetal liver cell cultures

M. D. Cappellini, C. G. Potter, W. G. Wood

Research output: Contribution to journalArticle

Abstract

Haemopoiesis in human fetal liver is almost entirely restricted to the erythroid series but when fetal liver cells were cultured under conditions established for the long-term maintenance of adult marrow haemopoiesis, a rapid switch to granulopoiesis was observed. Erythroid progenitor cells (BFU-E) rapidly disappeared, even though no humoral or cellular inhibitors of erythropoiesis could be detected, while myeloid progenitors (CFU-GM) increased in number. When the fetal liver cells were seeded onto stromal layers derived from adult marrow, in which endogenous haemopoiesis had ceased, granulopoiesis was established and maintained for more than a year, considerably longer than has previously been achieved with human haemopoietic cells.

Original languageEnglish
Pages (from-to)61-70
Number of pages10
JournalBritish Journal of Haematology
Volume57
Issue number1
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Hematology

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