TY - JOUR
T1 - Long-term idebenone treatment of vascular and degenerative brain disorders of the elderly
AU - Nappi, Guiseppe
AU - Bono, Giorgio
AU - Merlo, Paola
AU - Denaro, Alessandro
AU - Proietti, Roberto
AU - Martucci, Nicola
AU - Fioravanti, Mario
PY - 1992
Y1 - 1992
N2 - A multicentre study with an open experimental design was carried out on 118 patients suffering from mild to moderate cognitive decline due to cerebrovascular and degenerative disorders (chronic cerebrovascular disorders, CCVD; multi-infarct dementia, MID; aging brain, AB; dementia of Alzheimer's type, DAT). All patients, after a wash-out period of 3 weeks, were treated with idebenone (45 mg twice daily by oral route) for a period of 6 months. Behavioral and cognitive measures (Sandoz Clinical Assessment of Geriatrics, SCAG; Serial Learning Test) were applied to evaluate the long term therapeutical aspects. The results, analyzed by multivariate analysis of variance and χ2 test, showed a significant improvement of the cognitive profile in all patients, more evident in CCVD and AB groups. No remarkable side-effects were found in all groups of patients, thus confirming good tolerability of idebenone.
AB - A multicentre study with an open experimental design was carried out on 118 patients suffering from mild to moderate cognitive decline due to cerebrovascular and degenerative disorders (chronic cerebrovascular disorders, CCVD; multi-infarct dementia, MID; aging brain, AB; dementia of Alzheimer's type, DAT). All patients, after a wash-out period of 3 weeks, were treated with idebenone (45 mg twice daily by oral route) for a period of 6 months. Behavioral and cognitive measures (Sandoz Clinical Assessment of Geriatrics, SCAG; Serial Learning Test) were applied to evaluate the long term therapeutical aspects. The results, analyzed by multivariate analysis of variance and χ2 test, showed a significant improvement of the cognitive profile in all patients, more evident in CCVD and AB groups. No remarkable side-effects were found in all groups of patients, thus confirming good tolerability of idebenone.
KW - Cerebrovascular disorders
KW - Cognitive impairment
KW - Dementia
KW - Idebenone
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U2 - 10.1016/0167-4943(92)90061-8
DO - 10.1016/0167-4943(92)90061-8
M3 - Article
C2 - 15374365
AN - SCOPUS:0027071840
VL - 15
SP - 261
EP - 269
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
SN - 0167-4943
IS - 3
ER -