Long-term immunological changes in azathioprine-treated MS patients

E. Corsini; L. La Mantia; M. Gelati; A. Dufour; C. Milanese; G. Massa; A. Nespolo; A. Salmaggi

doi:10.1007/s100720070101

Long-term immunological changes in azathioprine-treated MS patients

E. Corsini, L. La Mantia, M. Gelati, A. Dufour, C. Milanese, G. Massa, A. Nespolo, A. Salmaggi

Research output: Contribution to journal › Article › peer-review

Abstract

The long-term immunological effects of azathioprine treatment have been investigated in 8 multiple sclerosis patients with different course of disease, chronic progressive (CP) or relapsing progressive (RP). We studied fluctuations in peripheral blood mononuclear cell subsets, IgG, IgM and soluble vascular cell adhesion molecule-1 (sVCAM-1), before and after 2 (T24) and 3 (T36) years of therapy. We observed a significant decrease in CD8⁺ cells over time and a trend to lower percentage of CD3-CD56⁺ cells at T24 and T36. CD4⁺CD45RA⁺ cells in MS patients were lower than in healthy controls before therapy and reached values similar to those of healthy controls at T24 and T36. The remaining immunological parameters did not show any significant fluctuations.

Original language	English
Pages (from-to)	87-91
Number of pages	5
Journal	Neurological Sciences
Volume	21
Issue number	2
DOIs	https://doi.org/10.1007/s100720070101
Publication status	Published - 2000

Keywords

Azathioprine
Multiple sclerosis
PBMNC subsets
sVCAM-1

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1007/s100720070101

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title = "Long-term immunological changes in azathioprine-treated MS patients",

abstract = "The long-term immunological effects of azathioprine treatment have been investigated in 8 multiple sclerosis patients with different course of disease, chronic progressive (CP) or relapsing progressive (RP). We studied fluctuations in peripheral blood mononuclear cell subsets, IgG, IgM and soluble vascular cell adhesion molecule-1 (sVCAM-1), before and after 2 (T24) and 3 (T36) years of therapy. We observed a significant decrease in CD8+ cells over time and a trend to lower percentage of CD3-CD56+ cells at T24 and T36. CD4+CD45RA+ cells in MS patients were lower than in healthy controls before therapy and reached values similar to those of healthy controls at T24 and T36. The remaining immunological parameters did not show any significant fluctuations.",

keywords = "Azathioprine, Multiple sclerosis, PBMNC subsets, sVCAM-1",

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T1 - Long-term immunological changes in azathioprine-treated MS patients

AU - Corsini, E.

AU - La Mantia, L.

AU - Gelati, M.

AU - Dufour, A.

AU - Milanese, C.

AU - Massa, G.

AU - Nespolo, A.

AU - Salmaggi, A.

PY - 2000

Y1 - 2000

N2 - The long-term immunological effects of azathioprine treatment have been investigated in 8 multiple sclerosis patients with different course of disease, chronic progressive (CP) or relapsing progressive (RP). We studied fluctuations in peripheral blood mononuclear cell subsets, IgG, IgM and soluble vascular cell adhesion molecule-1 (sVCAM-1), before and after 2 (T24) and 3 (T36) years of therapy. We observed a significant decrease in CD8+ cells over time and a trend to lower percentage of CD3-CD56+ cells at T24 and T36. CD4+CD45RA+ cells in MS patients were lower than in healthy controls before therapy and reached values similar to those of healthy controls at T24 and T36. The remaining immunological parameters did not show any significant fluctuations.

AB - The long-term immunological effects of azathioprine treatment have been investigated in 8 multiple sclerosis patients with different course of disease, chronic progressive (CP) or relapsing progressive (RP). We studied fluctuations in peripheral blood mononuclear cell subsets, IgG, IgM and soluble vascular cell adhesion molecule-1 (sVCAM-1), before and after 2 (T24) and 3 (T36) years of therapy. We observed a significant decrease in CD8+ cells over time and a trend to lower percentage of CD3-CD56+ cells at T24 and T36. CD4+CD45RA+ cells in MS patients were lower than in healthy controls before therapy and reached values similar to those of healthy controls at T24 and T36. The remaining immunological parameters did not show any significant fluctuations.

KW - Azathioprine

KW - Multiple sclerosis

KW - PBMNC subsets

KW - sVCAM-1

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Long-term immunological changes in azathioprine-treated MS patients

Abstract

Keywords

ASJC Scopus subject areas

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