Long-term intrathecal baclofen treatment in supraspinal spasticity

L. Saltuari, M. Kronenberg, M. J. Marosi, M. Kofler, L. Russegger, C. Rifici, P. Bramanti, [No Value] Gerstenbrand

Research output: Contribution to journalArticle


Baclofen, a derivative of gamma-amino butyric acid (GABA), is known to be a useful drug in spasticity treatment. To achieve a good therapeutic response higher oral dosages have to be administered related with central side effects. Intrathecal application of Baclofen in μg range dosages is proved to be effective in spinal spasticity. The efficiency of intrathecal Baclofen in patients suffering from supraspinal spasticity is discussed controversially. We report on 9 patents with long-term intrathecal Baclofen treatment, all of them responding well presentinsg a marked reeduced muscle tone. In most cases an improvement of motor performance and in two cases improved bladder function was observed. The therapeutical dosages administered to patients with supraspinal spasticity exceed those administered to patients with spinal spasticity for approximately 100% without provoking central side effects. Despite the risks connected with this method it has to be considered as treatment of choice in cases of severe supraspinal spasticity.

Original languageEnglish
Pages (from-to)195-207
Number of pages13
JournalActa Neurologica
Issue number3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Clinical Neurology

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    Saltuari, L., Kronenberg, M., Marosi, M. J., Kofler, M., Russegger, L., Rifici, C., Bramanti, P., & Gerstenbrand, N. V. (1992). Long-term intrathecal baclofen treatment in supraspinal spasticity. Acta Neurologica, 47(3), 195-207.