Long-term lifestyle changes after colorectal cancer screening: Randomised controlled trial

Paula Berstad, Magnus Løberg, Inger Kristin Larsen, Mette Kalager, Øyvind Holme, Edoardo Botteri, Michael Bretthauer, Geir Hoff

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective There is uncertainty whether cancer screening affects participant incentives for favourable lifestyle. The present study investigates long-term effects of colorectal cancer (CRC) screening on lifestyle changes. Design In 1999-2001, men and women drawn from the population registry were randomised to screening for CRC by flexible sigmoidoscopy ('invited-to-screening' arm) or to no-screening (control arm) in the Norwegian Colorectal Cancer Prevention trial. A subgroup of 3043 individuals in the 'invited-to-screening' and 2819 in the control arm, aged 50-55 years, randomised during 2001 had their lifestyle assessed by a questionnaire at inclusion and after 11 years (42% of cohort). The outcome was 11-year changes in lifestyle factors (body weight, smoking status, physical exercise, selected dietary habits) and in total lifestyle score (0-4 points, translating to the number of lifestyle recommendations adhered to). We compared outcomes in the two randomisation arms and attendees with positive versus negative findings. Results Total lifestyle scores improved in both arms. The improvement was smaller in the 'invited-to-screening' arm (score 1.43 at inclusion; 1.58 after 11 years) compared with the control arm (score 1.49 at inclusion; 1.67 after 11 years); adjusted difference -0.05 (95% CI -0.09 to -0.01; p=0.03). The change in the score was less favourable in screening attendees with a positive compared with negative screening result; adjusted difference -0.16 (95% CI -0.25 to -0.08; p

Original languageEnglish
Pages (from-to)1268-1276
Number of pages9
JournalGut
Volume64
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Early Detection of Cancer
Life Style
Colorectal Neoplasms
Randomized Controlled Trials
Sigmoidoscopy
Feeding Behavior
Random Allocation
Uncertainty
Registries
Motivation
Smoking
Body Weight
Exercise
Population

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Berstad, P., Løberg, M., Larsen, I. K., Kalager, M., Holme, Ø., Botteri, E., ... Hoff, G. (2015). Long-term lifestyle changes after colorectal cancer screening: Randomised controlled trial. Gut, 64(8), 1268-1276. https://doi.org/10.1136/gutjnl-2014-307376

Long-term lifestyle changes after colorectal cancer screening : Randomised controlled trial. / Berstad, Paula; Løberg, Magnus; Larsen, Inger Kristin; Kalager, Mette; Holme, Øyvind; Botteri, Edoardo; Bretthauer, Michael; Hoff, Geir.

In: Gut, Vol. 64, No. 8, 01.08.2015, p. 1268-1276.

Research output: Contribution to journalArticle

Berstad, P, Løberg, M, Larsen, IK, Kalager, M, Holme, Ø, Botteri, E, Bretthauer, M & Hoff, G 2015, 'Long-term lifestyle changes after colorectal cancer screening: Randomised controlled trial', Gut, vol. 64, no. 8, pp. 1268-1276. https://doi.org/10.1136/gutjnl-2014-307376
Berstad P, Løberg M, Larsen IK, Kalager M, Holme Ø, Botteri E et al. Long-term lifestyle changes after colorectal cancer screening: Randomised controlled trial. Gut. 2015 Aug 1;64(8):1268-1276. https://doi.org/10.1136/gutjnl-2014-307376
Berstad, Paula ; Løberg, Magnus ; Larsen, Inger Kristin ; Kalager, Mette ; Holme, Øyvind ; Botteri, Edoardo ; Bretthauer, Michael ; Hoff, Geir. / Long-term lifestyle changes after colorectal cancer screening : Randomised controlled trial. In: Gut. 2015 ; Vol. 64, No. 8. pp. 1268-1276.
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abstract = "Objective There is uncertainty whether cancer screening affects participant incentives for favourable lifestyle. The present study investigates long-term effects of colorectal cancer (CRC) screening on lifestyle changes. Design In 1999-2001, men and women drawn from the population registry were randomised to screening for CRC by flexible sigmoidoscopy ('invited-to-screening' arm) or to no-screening (control arm) in the Norwegian Colorectal Cancer Prevention trial. A subgroup of 3043 individuals in the 'invited-to-screening' and 2819 in the control arm, aged 50-55 years, randomised during 2001 had their lifestyle assessed by a questionnaire at inclusion and after 11 years (42{\%} of cohort). The outcome was 11-year changes in lifestyle factors (body weight, smoking status, physical exercise, selected dietary habits) and in total lifestyle score (0-4 points, translating to the number of lifestyle recommendations adhered to). We compared outcomes in the two randomisation arms and attendees with positive versus negative findings. Results Total lifestyle scores improved in both arms. The improvement was smaller in the 'invited-to-screening' arm (score 1.43 at inclusion; 1.58 after 11 years) compared with the control arm (score 1.49 at inclusion; 1.67 after 11 years); adjusted difference -0.05 (95{\%} CI -0.09 to -0.01; p=0.03). The change in the score was less favourable in screening attendees with a positive compared with negative screening result; adjusted difference -0.16 (95{\%} CI -0.25 to -0.08; p",
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