Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C

Francesca Romana Ponziani, Raffaella Viganò, Rosa Maria Iemmolo, Maria Francesca Donato, Maria Rendina, Pierluigi Toniutto, Luisa Pasulo, Maria Cristina Morelli, Patrizia Burra, Lucia Miglioresi, Manuela Merli, Daniele Di Paolo, Stefano Fagiuoli, Antonio Gasbarrini, Maurizio Pompili, L. Belli, G. E. Gerunda, M. Marino, R. Montalti, F. Di BenedettoN. De Ruvo, C. Rigamonti, M. Colombo, G. Rossi, A. Di Leo, L. Lupo, V. Memeo, R. Bringiotti, M. Zappimbulso, D. Bitetto, V. Vero, M. Colpani, E. Fornasiere, A. D. Pinna, M. C. Morelli, V. Bertuzzo, E. De Martin, M. Senzolo, G. M. Ettorre, U. Visco-Comandini, G. Antonucci, M. Angelico, G. Tisone, V. Giannelli, M. Giusto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. Aim: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11. ±. 3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p= 0.007), treatment duration >80% of the scheduled period (p= 0.027), and early virological response (p= 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p= 0.008). Conclusions: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.

Original languageEnglish
Pages (from-to)440-445
Number of pages6
JournalDigestive and Liver Disease
Volume46
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Hepatitis C
Liver
Antiviral Agents
Transplants
Recurrence
Survival Rate
Genotype
Maintenance
Survival
Virus Diseases
Therapeutics
Hepacivirus
Liver Transplantation
Transplant Recipients
RNA

Keywords

  • HCV antiviral treatment
  • Hepatitis C recurrence
  • Liver transplantation
  • Sustained viral response

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)

Cite this

Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C. / Ponziani, Francesca Romana; Viganò, Raffaella; Iemmolo, Rosa Maria; Donato, Maria Francesca; Rendina, Maria; Toniutto, Pierluigi; Pasulo, Luisa; Morelli, Maria Cristina; Burra, Patrizia; Miglioresi, Lucia; Merli, Manuela; Di Paolo, Daniele; Fagiuoli, Stefano; Gasbarrini, Antonio; Pompili, Maurizio; Belli, L.; Gerunda, G. E.; Marino, M.; Montalti, R.; Di Benedetto, F.; De Ruvo, N.; Rigamonti, C.; Colombo, M.; Rossi, G.; Di Leo, A.; Lupo, L.; Memeo, V.; Bringiotti, R.; Zappimbulso, M.; Bitetto, D.; Vero, V.; Colpani, M.; Fornasiere, E.; Pinna, A. D.; Morelli, M. C.; Bertuzzo, V.; De Martin, E.; Senzolo, M.; Ettorre, G. M.; Visco-Comandini, U.; Antonucci, G.; Angelico, M.; Tisone, G.; Giannelli, V.; Giusto, M.

In: Digestive and Liver Disease, Vol. 46, No. 5, 2014, p. 440-445.

Research output: Contribution to journalArticle

Ponziani, FR, Viganò, R, Iemmolo, RM, Donato, MF, Rendina, M, Toniutto, P, Pasulo, L, Morelli, MC, Burra, P, Miglioresi, L, Merli, M, Di Paolo, D, Fagiuoli, S, Gasbarrini, A, Pompili, M, Belli, L, Gerunda, GE, Marino, M, Montalti, R, Di Benedetto, F, De Ruvo, N, Rigamonti, C, Colombo, M, Rossi, G, Di Leo, A, Lupo, L, Memeo, V, Bringiotti, R, Zappimbulso, M, Bitetto, D, Vero, V, Colpani, M, Fornasiere, E, Pinna, AD, Morelli, MC, Bertuzzo, V, De Martin, E, Senzolo, M, Ettorre, GM, Visco-Comandini, U, Antonucci, G, Angelico, M, Tisone, G, Giannelli, V & Giusto, M 2014, 'Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C', Digestive and Liver Disease, vol. 46, no. 5, pp. 440-445. https://doi.org/10.1016/j.dld.2014.01.157
Ponziani, Francesca Romana ; Viganò, Raffaella ; Iemmolo, Rosa Maria ; Donato, Maria Francesca ; Rendina, Maria ; Toniutto, Pierluigi ; Pasulo, Luisa ; Morelli, Maria Cristina ; Burra, Patrizia ; Miglioresi, Lucia ; Merli, Manuela ; Di Paolo, Daniele ; Fagiuoli, Stefano ; Gasbarrini, Antonio ; Pompili, Maurizio ; Belli, L. ; Gerunda, G. E. ; Marino, M. ; Montalti, R. ; Di Benedetto, F. ; De Ruvo, N. ; Rigamonti, C. ; Colombo, M. ; Rossi, G. ; Di Leo, A. ; Lupo, L. ; Memeo, V. ; Bringiotti, R. ; Zappimbulso, M. ; Bitetto, D. ; Vero, V. ; Colpani, M. ; Fornasiere, E. ; Pinna, A. D. ; Morelli, M. C. ; Bertuzzo, V. ; De Martin, E. ; Senzolo, M. ; Ettorre, G. M. ; Visco-Comandini, U. ; Antonucci, G. ; Angelico, M. ; Tisone, G. ; Giannelli, V. ; Giusto, M. / Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C. In: Digestive and Liver Disease. 2014 ; Vol. 46, No. 5. pp. 440-445.
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abstract = "Background: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. Aim: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods: 436 Liver transplant recipients (74.1{\%} genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results: The overall sustained virological response rate was 40{\%} (173/436 patients), and the mean follow-up after liver transplantation was 11. ±. 3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97{\%} and a 10-year survival rate of 93{\%}; all but 6 (3{\%}) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p= 0.007), treatment duration >80{\%} of the scheduled period (p= 0.027), and early virological response (p= 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p= 0.008). Conclusions: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.",
keywords = "HCV antiviral treatment, Hepatitis C recurrence, Liver transplantation, Sustained viral response",
author = "Ponziani, {Francesca Romana} and Raffaella Vigan{\`o} and Iemmolo, {Rosa Maria} and Donato, {Maria Francesca} and Maria Rendina and Pierluigi Toniutto and Luisa Pasulo and Morelli, {Maria Cristina} and Patrizia Burra and Lucia Miglioresi and Manuela Merli and {Di Paolo}, Daniele and Stefano Fagiuoli and Antonio Gasbarrini and Maurizio Pompili and L. Belli and Gerunda, {G. E.} and M. Marino and R. Montalti and {Di Benedetto}, F. and {De Ruvo}, N. and C. Rigamonti and M. Colombo and G. Rossi and {Di Leo}, A. and L. Lupo and V. Memeo and R. Bringiotti and M. Zappimbulso and D. Bitetto and V. Vero and M. Colpani and E. Fornasiere and Pinna, {A. D.} and Morelli, {M. C.} and V. Bertuzzo and {De Martin}, E. and M. Senzolo and Ettorre, {G. M.} and U. Visco-Comandini and G. Antonucci and M. Angelico and G. Tisone and V. Giannelli and M. Giusto",
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T1 - Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C

AU - Ponziani, Francesca Romana

AU - Viganò, Raffaella

AU - Iemmolo, Rosa Maria

AU - Donato, Maria Francesca

AU - Rendina, Maria

AU - Toniutto, Pierluigi

AU - Pasulo, Luisa

AU - Morelli, Maria Cristina

AU - Burra, Patrizia

AU - Miglioresi, Lucia

AU - Merli, Manuela

AU - Di Paolo, Daniele

AU - Fagiuoli, Stefano

AU - Gasbarrini, Antonio

AU - Pompili, Maurizio

AU - Belli, L.

AU - Gerunda, G. E.

AU - Marino, M.

AU - Montalti, R.

AU - Di Benedetto, F.

AU - De Ruvo, N.

AU - Rigamonti, C.

AU - Colombo, M.

AU - Rossi, G.

AU - Di Leo, A.

AU - Lupo, L.

AU - Memeo, V.

AU - Bringiotti, R.

AU - Zappimbulso, M.

AU - Bitetto, D.

AU - Vero, V.

AU - Colpani, M.

AU - Fornasiere, E.

AU - Pinna, A. D.

AU - Morelli, M. C.

AU - Bertuzzo, V.

AU - De Martin, E.

AU - Senzolo, M.

AU - Ettorre, G. M.

AU - Visco-Comandini, U.

AU - Antonucci, G.

AU - Angelico, M.

AU - Tisone, G.

AU - Giannelli, V.

AU - Giusto, M.

PY - 2014

Y1 - 2014

N2 - Background: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. Aim: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11. ±. 3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p= 0.007), treatment duration >80% of the scheduled period (p= 0.027), and early virological response (p= 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p= 0.008). Conclusions: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.

AB - Background: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. Aim: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11. ±. 3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p= 0.007), treatment duration >80% of the scheduled period (p= 0.027), and early virological response (p= 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p= 0.008). Conclusions: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.

KW - HCV antiviral treatment

KW - Hepatitis C recurrence

KW - Liver transplantation

KW - Sustained viral response

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U2 - 10.1016/j.dld.2014.01.157

DO - 10.1016/j.dld.2014.01.157

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JO - Digestive and Liver Disease

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