Long-term melatonin supplementation does not recover the impairment of natural killer cell activity and lymphocyte proliferation in aging mice

Mauro Provinciali, Giuseppina Di Stefano, Daniele Bulian, Stefania Stronati, Nicola Fabris

Research output: Contribution to journalArticle

Abstract

In this study we evaluated the effect of long-term melatonin (MEL) treatment on the cytotoxic activity and number of natural killer (NK) cells and the proliferative response of spleen lymphocytes to phytohemagglutinin (PHA) or interleukin-2 (IL-2) in old mice. Seventeen-eighteen month-old Balb/c mice were supplemented with MEL (40-50μg/day/mouse) and sacrificed after eight months. The MEL supplementation was unable to recover the low levels of both endogenous and IL-2-induced NK cell activity found in old untreated mice. Also the NK cell number was unaffected by MEL treatment. The spleen lymphocyte proliferative response to both PHA and IL-2 was not different in old MEL-treated compared to old untreated mice. These results indicate that long-term MEL supplementation does not recover the age-related deterioration of NK cell activity and lymphocyte proliferative capacity.

Original languageEnglish
Pages (from-to)857-864
Number of pages8
JournalLife Sciences
Volume61
Issue number9
DOIs
Publication statusPublished - Jul 25 1997

Keywords

  • Aging
  • Lymphocyte proliferation
  • Melatonin
  • Mice
  • Natural killer cells
  • Neuroimmunomodulation

ASJC Scopus subject areas

  • Pharmacology

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