Long-term metabolic control and retinopathy in type I diabetes: ten-year follow-up.

R. Giansanti, M. Boemi, L. Amodio, P. Fioravanti, R. A. Rabini, P. Fumelli

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The causative relationship between metabolic control and long-term complications of diabetes is still under debate. Recent studies suggest that a strict glycemic control can often prevent the development of microcirculatory impairment but the role played by chronic hyperglycemia in the pathogenesis of retinopathy remains controversial. We report the results of a retrospective study of data collected on a ten-year period and concerning the relationship between glycemic control and retinopathy. A group of 46 Type I diabetic people was studied. Results indicate that the probability of developing retinopathy or of worsening the degree of a pre-existing retinopathy is higher in patients with poor metabolic control. Deterioration of metabolic control (increase of HbAlc% levels) appears to be related to a progression of retinal lesions. On the contrary, retinopathy is not influenced by aging and duration of diabetes mellitus.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalDiabetes Research
Issue number2
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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