Long-term molecular remission after conventional chemotherapy in a patient with Philadelphia-negative acute lymphoblastic leukemia

M. Ladetto, P. Corradini, M. Astolfi, S. Campana, C. Tarella, A. Pileri

Research output: Contribution to journalArticle

Abstract

Adult Philadelphia (Ph1) negative acute lymphoblastic leukemia (ALL) is usually treated with conventional chemotherapy regimens. Long-term disease- free survival is often achieved. The rearrangement of immunoglobulin heavy- chain genes has been used to evaluate minimal residual disease. A novel nested-polymerase chain reaction (PGR) approach was used here to study a patient in long-term complete remission [GR] after the BFM regimen. No evidence of tumor cell contamination was found in bone marrow cells collected after 93 months of CR. This finding supports the hypothesis that conventional chemotherapy can induce long-term molecular remission and cure in Ph1 negative ALL.

Original languageEnglish
Pages (from-to)159-161
Number of pages3
JournalHaematologica
Volume81
Issue number2
Publication statusPublished - 1996

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunoglobulin Heavy Chain Genes
Drug Therapy
Residual Neoplasm
Bone Marrow Cells
Disease-Free Survival
Polymerase Chain Reaction
Neoplasms

Keywords

  • Long-term molecular remission
  • Minimal residual disease
  • Philadelphia-negative acute lymphoblastic leukemia

ASJC Scopus subject areas

  • Hematology

Cite this

Long-term molecular remission after conventional chemotherapy in a patient with Philadelphia-negative acute lymphoblastic leukemia. / Ladetto, M.; Corradini, P.; Astolfi, M.; Campana, S.; Tarella, C.; Pileri, A.

In: Haematologica, Vol. 81, No. 2, 1996, p. 159-161.

Research output: Contribution to journalArticle

Ladetto, M. ; Corradini, P. ; Astolfi, M. ; Campana, S. ; Tarella, C. ; Pileri, A. / Long-term molecular remission after conventional chemotherapy in a patient with Philadelphia-negative acute lymphoblastic leukemia. In: Haematologica. 1996 ; Vol. 81, No. 2. pp. 159-161.
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