Long-term monitoring of tricyclic antidepressant plasma concentrations

H. Loo, A. K. Benyacoub, V. Rovei, C. A. Altamura, M. Vadrot, P. L. Morselli

Research output: Contribution to journalArticle

Abstract

Plasma levels of antidepressant drugs were measured in 17 depressed patients at roughly monthly intervals over follow-up periods of three to 26 months. Good results in seven were associated with small fluctuations in level from visit to visit, while big fluctuations were associated with poor outcome. Such fluctuations were probably from poor compliance or drug interaction from self-medication. Severe side effects and cardiotoxicity were associated with high levels.

Original languageEnglish
Pages (from-to)444-451
Number of pages8
JournalBritish Journal of Psychiatry
Volume137
Issue number5
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Neuroscience(all)
  • Psychiatry and Mental health

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  • Cite this

    Loo, H., Benyacoub, A. K., Rovei, V., Altamura, C. A., Vadrot, M., & Morselli, P. L. (1980). Long-term monitoring of tricyclic antidepressant plasma concentrations. British Journal of Psychiatry, 137(5), 444-451.