TY - JOUR
T1 - Long-term morbidity and mortality in Whipple's disease
T2 - a single-center experience over 20 years
AU - Schiepatti, Annalisa
AU - Nicolardi, Maria Luisa
AU - Marone, Piero
AU - Biagi, Federico
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Background: Little is known about long-term morbidity and mortality in Whipple's disease (WD). Aim: To describe morbidity and mortality in patients with WD on a long-term follow-up. Materials & methods: Comorbidities, mortality and causes of death were retrospectively registered. Results: A total of 35 patients with WD (9F, 54 ± 11 years) were followed-up for a median of 104 months. Nine patients developed ten complications; three patients died. A total of 31 severe comorbidities apparently unrelated to WD were found in 20 patients: preneoplastic/neoplastic disorders in seven, thromboembolic and cardiovascular events in seven, pneumonia in four, candidiasis in ten patients. Conclusion: WD is frequently complicated by potentially life-threatening infectious, neoplastic and thromboembolic disorders, thus highlighting the need for a life-long multidisciplinary follow-up.
AB - Background: Little is known about long-term morbidity and mortality in Whipple's disease (WD). Aim: To describe morbidity and mortality in patients with WD on a long-term follow-up. Materials & methods: Comorbidities, mortality and causes of death were retrospectively registered. Results: A total of 35 patients with WD (9F, 54 ± 11 years) were followed-up for a median of 104 months. Nine patients developed ten complications; three patients died. A total of 31 severe comorbidities apparently unrelated to WD were found in 20 patients: preneoplastic/neoplastic disorders in seven, thromboembolic and cardiovascular events in seven, pneumonia in four, candidiasis in ten patients. Conclusion: WD is frequently complicated by potentially life-threatening infectious, neoplastic and thromboembolic disorders, thus highlighting the need for a life-long multidisciplinary follow-up.
KW - chronic infections
KW - environmental microbiology
KW - morbidity
KW - mortality
KW - tropheryma whipplei
KW - Whipple’s disease
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U2 - 10.2217/fmb-2019-0315
DO - 10.2217/fmb-2019-0315
M3 - Article
C2 - 32662657
AN - SCOPUS:85090077301
VL - 15
SP - 847
EP - 854
JO - Future Microbiology
JF - Future Microbiology
SN - 1746-0913
ER -