Long-term morbidity and mortality in Whipple's disease: a single-center experience over 20 years

Annalisa Schiepatti; Maria Luisa Nicolardi; Piero Marone; Federico Biagi

doi:10.2217/fmb-2019-0315

Long-term morbidity and mortality in Whipple's disease: a single-center experience over 20 years

Annalisa Schiepatti, Maria Luisa Nicolardi, Piero Marone, Federico Biagi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Little is known about long-term morbidity and mortality in Whipple's disease (WD). Aim: To describe morbidity and mortality in patients with WD on a long-term follow-up. Materials & methods: Comorbidities, mortality and causes of death were retrospectively registered. Results: A total of 35 patients with WD (9F, 54 ± 11 years) were followed-up for a median of 104 months. Nine patients developed ten complications; three patients died. A total of 31 severe comorbidities apparently unrelated to WD were found in 20 patients: preneoplastic/neoplastic disorders in seven, thromboembolic and cardiovascular events in seven, pneumonia in four, candidiasis in ten patients. Conclusion: WD is frequently complicated by potentially life-threatening infectious, neoplastic and thromboembolic disorders, thus highlighting the need for a life-long multidisciplinary follow-up.

Original language	English
Pages (from-to)	847-854
Number of pages	8
Journal	Future Microbiology
Volume	15
DOIs	https://doi.org/10.2217/fmb-2019-0315
Publication status	Published - Jul 1 2020

Keywords

chronic infections
environmental microbiology
morbidity
mortality
tropheryma whipplei
Whipple’s disease

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

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title = "Long-term morbidity and mortality in Whipple's disease: a single-center experience over 20 years",

abstract = "Background: Little is known about long-term morbidity and mortality in Whipple's disease (WD). Aim: To describe morbidity and mortality in patients with WD on a long-term follow-up. Materials & methods: Comorbidities, mortality and causes of death were retrospectively registered. Results: A total of 35 patients with WD (9F, 54 ± 11 years) were followed-up for a median of 104 months. Nine patients developed ten complications; three patients died. A total of 31 severe comorbidities apparently unrelated to WD were found in 20 patients: preneoplastic/neoplastic disorders in seven, thromboembolic and cardiovascular events in seven, pneumonia in four, candidiasis in ten patients. Conclusion: WD is frequently complicated by potentially life-threatening infectious, neoplastic and thromboembolic disorders, thus highlighting the need for a life-long multidisciplinary follow-up.",

keywords = "chronic infections, environmental microbiology, morbidity, mortality, tropheryma whipplei, Whipple{\textquoteright}s disease",

author = "Annalisa Schiepatti and Nicolardi, {Maria Luisa} and Piero Marone and Federico Biagi",

year = "2020",

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doi = "10.2217/fmb-2019-0315",

language = "English",

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T2 - a single-center experience over 20 years

AU - Schiepatti, Annalisa

AU - Nicolardi, Maria Luisa

AU - Marone, Piero

AU - Biagi, Federico

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Background: Little is known about long-term morbidity and mortality in Whipple's disease (WD). Aim: To describe morbidity and mortality in patients with WD on a long-term follow-up. Materials & methods: Comorbidities, mortality and causes of death were retrospectively registered. Results: A total of 35 patients with WD (9F, 54 ± 11 years) were followed-up for a median of 104 months. Nine patients developed ten complications; three patients died. A total of 31 severe comorbidities apparently unrelated to WD were found in 20 patients: preneoplastic/neoplastic disorders in seven, thromboembolic and cardiovascular events in seven, pneumonia in four, candidiasis in ten patients. Conclusion: WD is frequently complicated by potentially life-threatening infectious, neoplastic and thromboembolic disorders, thus highlighting the need for a life-long multidisciplinary follow-up.

AB - Background: Little is known about long-term morbidity and mortality in Whipple's disease (WD). Aim: To describe morbidity and mortality in patients with WD on a long-term follow-up. Materials & methods: Comorbidities, mortality and causes of death were retrospectively registered. Results: A total of 35 patients with WD (9F, 54 ± 11 years) were followed-up for a median of 104 months. Nine patients developed ten complications; three patients died. A total of 31 severe comorbidities apparently unrelated to WD were found in 20 patients: preneoplastic/neoplastic disorders in seven, thromboembolic and cardiovascular events in seven, pneumonia in four, candidiasis in ten patients. Conclusion: WD is frequently complicated by potentially life-threatening infectious, neoplastic and thromboembolic disorders, thus highlighting the need for a life-long multidisciplinary follow-up.

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KW - environmental microbiology

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