Long-term morbidity and mortality in Whipple's disease: a single-center experience over 20 years

Annalisa Schiepatti, Maria Luisa Nicolardi, Piero Marone, Federico Biagi

Research output: Contribution to journalArticlepeer-review


Background: Little is known about long-term morbidity and mortality in Whipple's disease (WD). Aim: To describe morbidity and mortality in patients with WD on a long-term follow-up. Materials & methods: Comorbidities, mortality and causes of death were retrospectively registered. Results: A total of 35 patients with WD (9F, 54 ± 11 years) were followed-up for a median of 104 months. Nine patients developed ten complications; three patients died. A total of 31 severe comorbidities apparently unrelated to WD were found in 20 patients: preneoplastic/neoplastic disorders in seven, thromboembolic and cardiovascular events in seven, pneumonia in four, candidiasis in ten patients. Conclusion: WD is frequently complicated by potentially life-threatening infectious, neoplastic and thromboembolic disorders, thus highlighting the need for a life-long multidisciplinary follow-up.

Original languageEnglish
Pages (from-to)847-854
Number of pages8
JournalFuture Microbiology
Publication statusPublished - Jul 1 2020


  • chronic infections
  • environmental microbiology
  • morbidity
  • mortality
  • tropheryma whipplei
  • Whipple’s disease

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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