Long-term mortality and its predictors in patients with critical leg ischaemia

V. Bertele, F. Colombo, M. C. Roncaglioni, G. Tognoni

Research output: Contribution to journalArticlepeer-review


Objective: To assess the predictivity of predefined variables with respect to long-term mortality in a cohort of patients with chronic critical leg ischaemia (CLI). Design: Prospective observational study. Methods: Census offices were asked to release information on survival or death status of 574 patients with CLI 2 years after their recruitment in the study. Results: Of 522 patients with available information, 165 (31.6%) died within 2 years of hospital admission, mostly from vascular causes as expected. Among the variables considered, male sex, current smoking, arterial hypertension, diabetes mellitus, hypercholesterolaemia, obesity, history of myocardial infarction and low ankle systolic pressure showed no univariate association with mortality. Besides age ≤ 70 years (relative risk, RR 1.90; 95% confidence interval (CI) 1.30-2.70), only a history of stroke (RR 1.82; 95% CI 1.19-2.79) and major amputation (RR 1.90; 95% CI 1.30-2.80) were significantly associated with mortality. Conclusions: CLI is a critical condition of such severity that most of the recognised cardiovascular risk factors cannot further influence the fate of the patients, one-third of whom die within 2 years.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number2
Publication statusPublished - 1997


  • Critical leg ischaemia
  • Mortality
  • Peripheral vascular disease
  • Predictive variables

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

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