Long-term mortality patterns in a residential cohort exposed to inorganic selenium in drinking water

Marco Vinceti, Paola Ballotari, Craig Steinmaus, Carlotta Malagoli, Ferdinando Luberto, Marcella Malavolti, Paolo Giorgi Rossi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Selenium (Se) is a metalloid of considerable nutritional and toxicological importance in humans. To date, limited epidemiologic evidence exists about the health effects of exposure to this trace element in drinking water. We investigated the relationship between Se levels in water and mortality in the municipality of Reggio Emilia, Italy, where high levels of Se were previously observed in drinking water. From 1974 to 1985, 2065 residents consumed drinking water with Se levels close to the European standard of 10 μg/l, in its inorganic hexavalent form (selenate). Follow-up was conducted for the years 1986–2012 in Reggio Emilia and a lesser exposed comparison group of around 100,000 municipal residents, with comparable socio-demographic characteristics. Overall mortality from all causes, cardiovascular disease and cancer showed little evidence of differences. However, excess rate ratios were seen for some site specific cancers such as neoplasms of buccal cavity and pharynx, urinary tract, lymphohematopoietic tissue, melanoma, and two neurodegenerative diseases, Parkinson's disease and amyotrophic lateral sclerosis. Excess mortality in the exposed cohort for specific outcomes was concentrated in the first period of follow-up (1986–1997), and waned starting 10 years after the high exposure ended. We also found lower mortality from breast cancer in females during the first period of follow-up. When we extended the analysis to include residents who had been consuming the high-selenium drinking water for a shorter period, mortality rate ratios were also increased, but to a lesser extent. Overall, we found that the mortality patterns related to long-term exposure to inorganic hexavalent selenium through drinking water were elevated for several site-specific cancers and neurodegenerative disease.

Original languageEnglish
Pages (from-to)348-356
Number of pages9
JournalEnvironmental Research
Volume150
DOIs
Publication statusPublished - Oct 1 2016

Fingerprint

Selenium
selenium
Drinking Water
drinking water
mortality
Mortality
cancer
Neurodegenerative diseases
Neurodegenerative Diseases
Neoplasms
Metalloids
Selenic Acid
selenate
Cheek
cardiovascular disease
Amyotrophic Lateral Sclerosis
Trace Elements
Pharynx
Urinary Tract
Toxicology

Keywords

  • Cancer
  • Cardiovascular disease
  • Cohort study
  • Drinking water
  • Mortality
  • Neurologic disease
  • Selenium

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry

Cite this

Long-term mortality patterns in a residential cohort exposed to inorganic selenium in drinking water. / Vinceti, Marco; Ballotari, Paola; Steinmaus, Craig; Malagoli, Carlotta; Luberto, Ferdinando; Malavolti, Marcella; Rossi, Paolo Giorgi.

In: Environmental Research, Vol. 150, 01.10.2016, p. 348-356.

Research output: Contribution to journalArticle

Vinceti, Marco ; Ballotari, Paola ; Steinmaus, Craig ; Malagoli, Carlotta ; Luberto, Ferdinando ; Malavolti, Marcella ; Rossi, Paolo Giorgi. / Long-term mortality patterns in a residential cohort exposed to inorganic selenium in drinking water. In: Environmental Research. 2016 ; Vol. 150. pp. 348-356.
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