Long-term naltrexone treatment modifies luteinizing hormone secretory amplitude in polycistic ovary syndrome

R. E. Nappi; F. Petraglia; A. Bacchi-Modena; L. Benassi; A. D. Genazzani; G. Comitini; C. Nappi; A. R. Genazzani

Long-term naltrexone treatment modifies luteinizing hormone secretory amplitude in polycistic ovary syndrome

R. E. Nappi, F. Petraglia, A. Bacchi-Modena, L. Benassi, A. D. Genazzani, G. Comitini, C. Nappi, A. R. Genazzani

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To evaluate the neuroendocrine effect of naltrexone in the long-term treatment of polycystic ovary syndrome. Methods: The chronobiological secretory characteristics of the pituitary hormones FSH, LH, PRL, and cortisol were investigated over a period of 8 hours in a group of polycystic ovary syndrome patients before and after treatment with naltrexone (50 mg per os daily for 28 days). Results: No significant changes in integrated LH mean values and mean LH pulse frequency were found, whereas the mean LH pulse amplitude was significantly lower (p

Original language	English
Pages (from-to)	64-68
Number of pages	5
Journal	Italian Journal of Gynaecology and Obstetrics
Volume	5
Issue number	2
Publication status	Published - 1993

ASJC Scopus subject areas

Obstetrics and Gynaecology

Cite this

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title = "Long-term naltrexone treatment modifies luteinizing hormone secretory amplitude in polycistic ovary syndrome",

abstract = "Objective: To evaluate the neuroendocrine effect of naltrexone in the long-term treatment of polycystic ovary syndrome. Methods: The chronobiological secretory characteristics of the pituitary hormones FSH, LH, PRL, and cortisol were investigated over a period of 8 hours in a group of polycystic ovary syndrome patients before and after treatment with naltrexone (50 mg per os daily for 28 days). Results: No significant changes in integrated LH mean values and mean LH pulse frequency were found, whereas the mean LH pulse amplitude was significantly lower (p",

author = "Nappi, {R. E.} and F. Petraglia and A. Bacchi-Modena and L. Benassi and Genazzani, {A. D.} and G. Comitini and C. Nappi and Genazzani, {A. R.}",

year = "1993",

language = "English",

volume = "5",

pages = "64--68",

journal = "Italian Journal of Gynaecology and Obstetrics",

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TY - JOUR

T1 - Long-term naltrexone treatment modifies luteinizing hormone secretory amplitude in polycistic ovary syndrome

AU - Nappi, R. E.

AU - Petraglia, F.

AU - Bacchi-Modena, A.

AU - Benassi, L.

AU - Genazzani, A. D.

AU - Comitini, G.

AU - Nappi, C.

AU - Genazzani, A. R.

PY - 1993

Y1 - 1993

N2 - Objective: To evaluate the neuroendocrine effect of naltrexone in the long-term treatment of polycystic ovary syndrome. Methods: The chronobiological secretory characteristics of the pituitary hormones FSH, LH, PRL, and cortisol were investigated over a period of 8 hours in a group of polycystic ovary syndrome patients before and after treatment with naltrexone (50 mg per os daily for 28 days). Results: No significant changes in integrated LH mean values and mean LH pulse frequency were found, whereas the mean LH pulse amplitude was significantly lower (p

AB - Objective: To evaluate the neuroendocrine effect of naltrexone in the long-term treatment of polycystic ovary syndrome. Methods: The chronobiological secretory characteristics of the pituitary hormones FSH, LH, PRL, and cortisol were investigated over a period of 8 hours in a group of polycystic ovary syndrome patients before and after treatment with naltrexone (50 mg per os daily for 28 days). Results: No significant changes in integrated LH mean values and mean LH pulse frequency were found, whereas the mean LH pulse amplitude was significantly lower (p

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M3 - Article

AN - SCOPUS:0027164982

VL - 5

SP - 64

EP - 68

JO - Italian Journal of Gynaecology and Obstetrics

JF - Italian Journal of Gynaecology and Obstetrics

SN - 1121-8339

IS - 2

ER -

Long-term naltrexone treatment modifies luteinizing hormone secretory amplitude in polycistic ovary syndrome

Abstract

ASJC Scopus subject areas

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