Abstract
Objective: To evaluate the neuroendocrine effect of naltrexone in the long-term treatment of polycystic ovary syndrome. Methods: The chronobiological secretory characteristics of the pituitary hormones FSH, LH, PRL, and cortisol were investigated over a period of 8 hours in a group of polycystic ovary syndrome patients before and after treatment with naltrexone (50 mg per os daily for 28 days). Results: No significant changes in integrated LH mean values and mean LH pulse frequency were found, whereas the mean LH pulse amplitude was significantly lower (p
| Original language | English |
|---|---|
| Pages (from-to) | 64-68 |
| Number of pages | 5 |
| Journal | Italian Journal of Gynaecology and Obstetrics |
| Volume | 5 |
| Issue number | 2 |
| Publication status | Published - 1993 |
ASJC Scopus subject areas
- Obstetrics and Gynaecology
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Nappi, R. E., Petraglia, F., Bacchi-Modena, A., Benassi, L., Genazzani, A. D., Comitini, G., Nappi, C., & Genazzani, A. R. (1993). Long-term naltrexone treatment modifies luteinizing hormone secretory amplitude in polycistic ovary syndrome. Italian Journal of Gynaecology and Obstetrics, 5(2), 64-68.