Long Term Non-invasive Ventilation in Children With Central Hypoventilation

Maria Giovanna Paglietti, Irene Esposito, Manuela Goia, Elvira Rizza, Renato Cutrera, Elisabetta Bignamini

Research output: Contribution to journalReview articlepeer-review


Central hypoventilation (CH) is a quite rare disorder caused by some congenital or acquired conditions. It is featured by increased arterial concentration of serum carbon dioxide related to an impairment of respiratory drive. Patients affected by CH need to be treated by mechanical ventilation in order to achieve appropriate ventilation and oxygenation both in sleep and wakefulness. In fact, in severe form of Congenital Central Hypoventilation Syndrome (CCHS) hypercarbia can be present even during the day. Positive pressure ventilation via tracheostomy is the first therapeutic option in this clinical condition, especially in congenital forms. Non-Invasive ventilation is a an option that must be reserved for more stable clinical situations and that requires careful monitoring over time.

Original languageEnglish
Article number288
JournalFrontiers in Pediatrics
Publication statusPublished - Jun 19 2020


  • arterial concentration of serum carbon dioxide
  • central apnea
  • central hypoventilation
  • children
  • non-invasive ventilation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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